Title: Effects of Losartan on vascular endothelial function in patients with essential hypertension and its clinical significance
Abstract: AIM To investigate the changes of vascular endothelial function in patients with essential hypertension and effects of Losartan on the patients.METHODS The plasma levels of endothelin(ET),nitric oxide(NO),von Willebrand Factor(vWF),and plate α-granule membrane protein(GMP140) were measured as the indexes of endothelial function.Forty-five patients with essential hypertension were treated with Losartan for 4 weeks and the changes of vascular endothelial function were investigated.RESULTS The plasma ET,vWF and GMP140 in hypertensive patients before treatment were significantly higher than those in normal control and NO/ET decreased in hypertensive group(P0.05,P0.01).After 4 weeks' treatment,the plasma ET,vWF and GMP140 in hypertensive group were decreased markedly(P0.05,P0.01).The plasma NO and NO/ET were increased and NO was higher than that in normal control(P0.05,P0.01).ET was positive correlated to blood total cholesterol(TC) and systolic blood pressure(SBP).NO and NO/ET were negatively related to fasting blood sugar,SBP and triglyceride,while NO/ET was positive correlated to high density lipoprotein(HDL).GMP140 and vWF were negative correlated to HDL but GMP140 was positively related to TC(P0.05,P0.01).CONCLUSION Endothelial functions are damaged in patients with essential hypertension.The indexes of endothelial function are related to the systolic blood pressure,blood glucose and lipid.Losartan can improve the vascular endothelial functions in patients with essential hypertension.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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