Title: The efficacy and the safety of doxazosin in treatment of hypertension
Abstract: Objective To evaluate the efficacy and safety of doxazosin in the treatment of hypertension. Methods Two hundred and twenty patients with mild or moderate hypertension were randomly assigned to receive doxazosin 2 - 6mg/d or terazosin 2 -6mg/d for 8 weeks. A trough sitting DBP/SBP and HR were measured before and biweekly after medication. Adverse effects were recorded. Blood biochemical tests were studied before and after taking drugs. Doxazosin and Terazosin were added to 4 mg/d if DBP was 90 mmHg after 2 weeks and to 6 mg/d after 4 weeks. Results After 8 weeks the total response rate was 74.77% in doxazosin group and 76.52% in terazosin group (P0.05) .A trough sitting DBP/SBP was effectively reduced after medication. No sevius adverse effects were recorded. Conclusion Both doxazosin and terazosin are effective and safe drugs to decrease high blood pressure.
Publication Year: 2003
Publication Date: 2003-01-01
Language: en
Type: article
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