Title: The comparison of efficacy and safety between doxazosin and terazosin on the treatment of primary hypertension
Abstract: Objective:To compare the efficacy and the safety of doxazosin and terazosin on the treatment of primary hypertension.Methods:This study was a randomized,single-blinded and parallel controlled trial. 63 eligible mild and moderate hypertension patients were divided randomly into trial group (doxazosin) and control group (terazosin).The patients took initial dosage of 2mg per day and gradually increased to a dosage of 2-8 mg per day. Treatment lasted for 4 weeks. ECG, general physical examination and blood biochemical tests as well as blood and urine routines were performed before and after the trial.Results:(1) After 4 weeks treatment, the rate of effectiveness of doxazosin group was 80.7%, and that of terazosin group was 70.0%, there were no significant difference in effective rate between doxazosin and terazosin.(2) After 4 weeks treatment, the SBP and DBP of doxazosin group decreased 10.81% and 10.70%, terazosin group decreased 10.01% and 11.47%.No significant difference was observed in this trial. (3) The effective dosage was 2-4 mg per day in the doxazosin group and 2-8 mg per day in the terazosin group. (4)The incidence of ADR events of two groups were similar (doxazosin group 25.8% and terazosin group 33.3%).The most common ADR were mild dizziness, headache, palpitation or posture hypotension which can be remitted shortly. No posture hypotension was found in the doxazosin group.Conclusion:Doxazosin, 2-6mg,once daily is effective and safe for the treatment of mild and moderate hypertension.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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