Title: Expression and application values of immunohistochemical indexes in breast cancer tissue
Abstract: Objective To explore the expressions and significance of immunohistochemical indexes including Ki67,VEGF,p53 and C-erb B-2 in breast cancer tissue. Methods 70 patients with breast cancer admitted into our hospital from April 2012 to April 2014 were selected as research objects. Pathological tissue was taken after surgery and expression levels of Ki67,VEGF,p53 and C-erb B-2 in breast cancer tissue were detected by immunohistochemical method and correlations of pathological factors in breast cancer were analyzed. Results The highest positive expression rate in breast cancer tissue was Ki67 accounting for 75.71%,and then C-erb B-2 for 67.14%.Expression level of Ki67 had an obvious correlation with neoplasm staging in breast cancer patients. The higher cancer staging was,the higher positive rate of Ki67 became in mammary tissue,expression of C-erb B-2 positive rate of breast cancer patients related to age,the younger,breast C-erb B-2 positive rate was higher,p53 and positive rate of VEFG had no embodied obvious correlation with patient age,tumor size,tumor staging. Conclusion Positive rate of Ki67 expression in mammary tissue in breast cancer patients has a positive correlation with cancer staging. C-erb B-2 expression level has a close relation with the age of patient. The positive expression of Ki67 is positively correlated with the expression of C-erb B-2 and p53,and the Ki67 can be used as an important marker for evaluating the progression of breast cancer.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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