Title: Down-regulated Expression of S100P in Gastric Cancer and Its Significance
Abstract: Objective To investigate the expression of S100P on RNA and protein levels in relation to clinicopathological features with gastric cancer patients.Methods Expression of S100P in primary gastric cancer(n=93) was analyzed using immunohistochemistry.Then,immunoblotting and RT-PCR were conducted on part of immunohistochemical-positively stained gastric cancer tissues and matched gastric mucosas.Results The immunohistochemical staining for S100P was predominantly nuclear with some cytoplasmic staining in normal gastric mucosa.As a result,52.7%(49/93) of primary tumors and almost all the normal gastric mucosa were stained positively and S100P showed down-regulated expression in gastric cancer than in normal gastric mucosa.Further analysis with clinicopathologic data showed that the relative higher S100P expression strongly correlated with tumor infiltration depth(P=0.006) and tumor size(P=0.001).Meanwhile,the expression of S100P between RNA and protein level(results from immunohistochemistry) was closely correlated(P=0.024).But it can not be used as a dependent prognosis factor.Conclusion S100P was down-regulated in gastric cancer;S100P expression correlated with tumor infiltration depth and tumor size;Down-regulated expression of S100P can be used as a supporting marker for prognosis prediction.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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