Title: EXPRESSION OF CyclinD1 AND P27 AND THEIR CLINICAL SIGNIFICANCE IN GASTRIC CARCINOMA
Abstract: Objective To investigate the expression of CyclinD1 and P27 in gastric cancer and their clinical significance.Methods The expression of CyclinD1 and P27 were determinded in normal gastric tissue,the adjacent cancer tissue and gastric cancer with the immunohistochemistry and tissue microarry technique. Results In normal gastric tissue,the adjacent cancer tissue and gastric cancer,positive immuostaining of cyclinD1 were 17.6%,32.7%,65.5%,respectively;While positive immuostaining of P27 were 61.9%,23.9%,13.3%,respectively.The expressions of CyclinD1 and P27 were significantly different between the three tissues(H=54.35,46.92;P0.01).Expression of CyclinD1 was negatively correlated with expression of P27(r=-0.209,P0.05).The high expression of CyclinD1 and the low expression of P27 were correlated with depth of invasion and lymph node metastasis(χ2=4.86-9.04,P0.05). Conclusion The results suggest that high expression of CyclinD1 and low expression of P27 may play an important role in the development of gastric cancer and be related to the prognosis of the disease.Tissue microarry is an efficient,low consume and strong comparability technique in the study of human pathology.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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