Title: The effect of prolonged hyperoxia on neonatal rat lung
Abstract:Objective: To determine the effect of prolonged hyperoxia on neonatal rat lung. Methods: Full-term newborn rats were continuously exposed to oxygen (85% O 2) or room air (21% O 2) after birth. Lung hi...Objective: To determine the effect of prolonged hyperoxia on neonatal rat lung. Methods: Full-term newborn rats were continuously exposed to oxygen (85% O 2) or room air (21% O 2) after birth. Lung histological change, collagen area; superoxide dismutase (SOD) activity and concentration of malondialdehyde (MDA) in the lung were monitered on days 1, 3, 7, 14 and 21 in hyperoxia groups and controls. Results: Compared with air group, the arrest of lung development was accompanied by interstitial fibrosis and increased collagen deposition, which was evident after 7d of oxygen exposure, increasing through 21d; Level of MDA in the lung was increased at 3d and reached a peak at 7d, then decreased. But SOD activities changed a little later with an increase at 7d, continuously to 21d. Conclusion: With prolonged hyperoxia exposure, the oxidant injury appears to lead to an arrest of lung development in neonatal rats and lung fibrosis with the increase of collagen.Read More
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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