Title: Expressions and Clinical Significance of MMP-7 mRNA Detected by ISH in Colon Carcinoma Tissue
Abstract: Objective To investigate the expressions and significance of MMP-7 mRNA in colon carcinoma tissue.Methods The expression of MMP-7 mRNA in colon carcinoma and distant normal colon mucosa tissue were detected by in situ hybridization.Results The positive rates of MMP-7 mRNA expression in colon carcinoma and distant normal colon mucosa tissues were 64.7%and 37.5% respectively.The positive expression of MMP-7 mRNA in colon carcinoma tissue was significantly higher than that in distant normal colon mucosa tissue(χ2=8.732,P=0.003).The expression rates of MMP-7 mRNA in patients with poor differentiation,lymph node metastasis,deeper infiltration depth and high Dukes' staging were increased with significant differences with that of the corresponding cases(P0.05).Conclusion The expression of MMP-7 mRNA may be closely associated with progression and metastasis of colon carcinoma.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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