Title: Effects of allicin on proliferation and telomerase activity in cne-2z cells
Abstract:Objective To study the effect on proliferation and telomerase activity of CNE-2Z cells treated by allicin.Methods CNE-2Z cells were treated by allicin With different concentrations.Then the inhibiting...Objective To study the effect on proliferation and telomerase activity of CNE-2Z cells treated by allicin.Methods CNE-2Z cells were treated by allicin With different concentrations.Then the inhibiting effects and changes of telomerase activity in CNE-2Z cells were detected by MTT assay and TRAP-PCR-ELISA.Results The proliferation of CNE-2Z cells treated with allicin was significantly inhibited,and it depended on density and time.Telomerase activity of CNE-2Z cells treated with allicin at different concentrations was significantly inhibited,and effects were also depended on density and time.Conclusion Allicin can inhibit the telomerase activity of CNE-2Z cells.It may be one of important regulatory mechanisms in the anti-tumor mechanism.Read More
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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