Abstract:The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It recognizes multiple classes of ligands, such as advance...The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It recognizes multiple classes of ligands, such as advanced glycation end products, amphoterin/HMGB1 proteins, S100/calgranulin and amyloid-beta peptides. RAGE has a C-truncated secretory isoform of the receptor protein that termed soluble RAGE (sRAGE). RAGE/ligand interaction activate several signal transduction pathways, among them nuclear factor-κB is the most important one. RAGE not lnly participates in the development of diabetic complications, but also is closely related to inflammation, tumor invasion and metastasis, nerve rebirth and Alzheimer′s disease. Blockade of ligand-RAGE interaction with sRAGE or RAGE-specific antibody can stop the effect that RAGE produce. It is suggested that blockade of the RAGE axis may be a new target for therapeutic intervention in diabetic complications and inflammatory disorders.Read More
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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