Publication Information

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101, 123, 147], 'Columbia': [80, 102, 124, 148, 2325], 'University,': [81, 103, 125, 149, 2326], 'New': [82, 104, 126, 150, 2333], 'York.': [83, 105, 127, 151], ',': [84, 106], 'HarjaEvis': [86], 'Harja': [87], 'MoserBernhard': [108], 'SchmidtAnn': [131], 'Originally': [152], 'published1': [153], 'May': [154], '2005https://doi.org/10.1161/01.ATV.0000164804.05324.8bArteriosclerosis,': [155], 'Biology.': [159], '2005;25:879–882The': [160], 'advanced': [163, 2864, 2916, 3000, 3149, 3193, 3272, 3452, 3506, 3566, 3572, 3651, 3776, 3812, 3952, 4028], 'glycation': [164, 191, 2865, 2917, 3001, 3150, 3194, 3273, 3453, 3507, 3567, 3652, 3777, 3813, 3953, 4029], 'endproducts': [165, 2918, 3002, 3195], '(RAGE)': [166, 2545, 2729, 3003, 3197, 3961], 'is': [167, 226, 673, 677, 849, 985, 993, 1029, 1095, 1157, 1192, 1253, 1350, 1541, 1564, 1602, 2159, 2204, 2286, 2299, 2546, 3041], 'a': [168, 183, 203, 227, 294, 367, 380, 385, 456, 990, 1016, 1089, 1396, 1453, 1591, 1619, 1814, 1956, 2130, 2145, 2287, 2290, 2300, 2303, 2354, 2408, 2412, 2547, 2552, 2822, 2962, 2991, 3941, 4145], 'multi-ligand': [169], 'member': [170], 'immunoglobulin': [173], 'superfamily': [174], 'cell': [176, 881, 898, 939, 1044, 1120, 2414, 2557], 'surface': [177, 882, 899, 940, 1045, 1121, 2415], 'molecules.1': [178], 'Although': [179, 896, 1080, 1652], 'first': [180, 479, 1318], 'described': [181], 'as': [182, 242, 384, 406, 408, 434, 566, 568, 579, 608, 806, 822, 886, 1101, 1116, 1126, 1168, 1369, 1410, 1428, 1491, 1535, 1648, 1761, 1813, 2032, 2076, 2256, 2821], 'receptor': [184, 206, 572, 878, 941, 1122, 1203, 1408, 1467, 1572, 2416, 2544, 2589, 2819, 2862, 2914, 2957, 2998, 3147, 3191, 3270, 3504, 3570, 3774, 3810, 3958, 4026], 'AGEs,': [186], 'products': [188, 2867, 3152, 3455, 3509, 3654, 3779, 3815, 4031], 'nonenzymatic': [190], 'oxidation': [193], 'proteins/lipids,': [195], 'later': [196], 'studies': [197, 476, 650, 954, 1141, 1588, 1656, 1999, 2093, 2238], 'indicated': [198], 'that': [199, 276, 481, 652, 675, 697, 791, 827, 850, 906, 957, 989, 1031, 1084, 1097, 1159, 1195, 1217, 1254, 1286, 1403, 1436, 1482, 1506, 1516, 1543, 1567, 1590, 1633, 1672, 1783, 1902, 1950, 2021, 2135, 2162, 2205], 'RAGE': [200, 225, 251, 288, 363, 391, 423, 565, 632, 676, 698, 714, 740, 773, 900, 1054, 1138, 1229, 1423, 1437, 1520, 1601, 1678, 1710, 1739, 1752, 1775, 1841, 2022, 2255, 2406, 2506, 2625, 2674, 2820, 2956, 3038, 3077, 3116, 3317, 3535, 3705], 'was': [201, 274, 285, 364, 605, 638, 699, 820, 1434, 1438], 'also': [202], 'signal': [204, 629, 1778], 'transduction': [205, 630, 1779], 'proinflammatory': [208, 2410], 'S100/calgranulins': [209], 'amphoterin': [211], '(or': [212], 'high': [213, 1962], 'mobility': [214], 'group': [215, 4063], 'box': [216], '1': [217, 2015, 2341, 3050], '[HMGB1])': [218], 'amyloid-β–peptide': [220], 'β-sheet': [222], 'fibrils.2–4': [223], 'Additionally,': [224, 1614], 'counter-receptor': [228], 'Mac-1.5': [230], 'These': [231, 1283, 1469, 1947], 'ligands': [232, 252, 289, 569, 1200, 1405, 1740, 1776], 'may': [233, 253, 290, 316, 1024, 1037, 1055, 1087, 1109, 1124, 1174, 1204, 1675, 2023, 2044, 2168, 2232], 'be': [234, 291, 916, 935, 1025, 1034, 1088, 1175, 1230, 1511, 1830, 1955, 2101, 2126, 2262], 'generated': [235, 376, 853, 910, 936], 'accumulate': [237], 'in': [238, 255, 268, 277, 301, 332, 413, 471, 524, 533, 538, 559, 573, 596, 612, 620, 625, 634, 653, 678, 690, 701, 711, 727, 741, 746, 751, 771, 901, 918, 964, 1066, 1132, 1246, 1268, 1287, 1316, 1457, 1460, 1473, 1484, 1537, 1610, 1618, 1690, 1746, 1843, 1876, 1885, 1933, 1992, 2012, 2027, 2041, 2094, 2117, 2171, 2192, 2211, 2219, 2310, 2511, 2630, 2683, 2733, 2831, 2872, 2920, 2931, 3004, 3048, 3119, 3154, 3206, 3230, 3318, 3379, 3387, 3456, 3512, 3517, 3577, 3611, 3707, 3784, 3822, 3842, 3888, 3965, 4033, 4067, 4126, 4147, 4187], 'diverse': [239, 1057], 'settings,': [240], 'such': [241, 433, 578, 885, 1100, 1167, 1208, 1368, 1409, 1427, 1490, 1660, 1760, 1911, 2031, 2042, 2075, 2118], 'diabetes,': [243, 787, 3969], 'renal': [244, 1763], 'failure,': [245, 1764], 'neurodegeneration,': [246], 'autoimmunity/inflammatory': [247], 'milieux,': [248], 'aging.': [250], 'synergize': [254], 'tissues': [256], 'primed': [257], 'by': [258, 346, 591, 734, 808, 867, 883, 931, 1021, 1062, 1135, 1331, 1353, 1650, 1734, 1897, 2035, 2229, 2587, 3266, 3696], 'genetic': [259, 1568, 1673], 'and/or': [260, 665, 888, 1128, 1716, 1744, 2048], 'environmental': [261, 1526], 'triggers': [262], 'amplify': [264, 1797], 'perturbation.': [265], 'For': [266], 'example,': [267, 1173], 'case': [270, 540], 'Mac-1,': [272], 'it': [273, 1028, 1094, 1156, 1193, 1394, 1433, 1514, 1540, 1565, 2133, 2160, 2206, 2249], 'demonstrated': [275], 'presence': [279, 598, 1278, 1362], 'S100,': [281], 'RAGE–Mac-1': [283], 'interaction': [284], 'augmented.5': [286], 'Thus,': [287, 1534], 'pieces': [292], 'scaffold': [295, 2355], 'that,': [296], 'together,': [297, 648], 'magnify': [298], 'inflammatory': [299, 466, 483, 1107, 1165, 1413, 1719, 1788, 1849, 1973, 2029, 2151, 2556, 2827], 'mechanisms': [300, 486, 930, 1036, 1720], 'tissues.': [303], 'If': [304, 1792], 'left': [305, 1793], 'unchecked,': [306, 1794], 'RAGE-mediated': [307], 'sustained': [308], 'inflammation,': [309], 'coupled': [310], 'with': [311, 359, 416, 502, 526, 616, 642, 716, 748, 799, 829, 1276, 1292, 1387, 1501, 1604, 1635, 1663, 1748, 1878, 1969, 1978, 2065, 3043, 3159, 3209, 3382, 3458, 3514, 3818, 3883, 4038], 'failure': [312], 'regenerative': [314], 'mechanisms,': [315, 1780], 'lead': [317, 1784], 'irreversible': [319], 'tissue': [320, 435, 1722, 1800, 1826, 2681, 3321], 'injury.1See': [321], 'page': [322], '1032Ligand–RAGE': [323], 'Axis:': [324], 'Breaking': [325], 'CycleThese': [327], 'concepts': [328, 1470, 1991], 'have': [329, 1622, 4144], 'been': [330], 'tested': [331], 'rodent': [333, 654, 2216], 'models': [334], 'exaggerated': [336, 2184], 'neointimal': [337, 522, 594, 668, 2185, 2731, 2779], 'expansion,': [338, 523], 'hallmark': [340], 'atherosclerosis': [342, 405, 504, 687, 1267, 1446, 2148, 2189, 2586, 2629], 'restenosis,': [344], 'triggered': [345, 2034], 'chronic': [347], 'hyperglycemia': [348, 1492], 'or': [349, 624, 645, 1105, 1372, 1447, 1449, 1493, 1573, 1639, 1770, 1853, 1867, 2087, 2245, 2258], 'acute': [350, 609, 2070], 'physical': [351, 666, 1766], 'stress.': [352], 'In': [353, 419, 444, 777, 1151, 1560, 1724, 1802], 'apolipoprotein': [354, 398, 499, 2632, 2688], 'E–null': [355, 399, 500], 'mice': [356, 400, 415, 501, 562, 614, 627, 2179], 'rendered': [357], 'diabetic': [358, 397, 414, 492, 513, 551, 704, 729, 743, 1611, 2585, 2631, 2687, 3051, 3155, 4036], 'streptozotocin,': [360], 'blockade': [361, 421, 2626], 'accomplished': [365], 'using': [366, 735, 851], 'soluble': [368, 373, 871, 2084, 2088, 2588, 2861, 2960, 3503, 3809, 4025], 'form': [369], 'receptor,': [372], '(s)': [374], 'RAGE,': [375, 607, 619, 856, 1123, 1782], 'purified': [378], 'from': [379, 875, 912, 937, 1040, 1183, 1525, 1869, 1916, 1920, 2215, 2292], 'baculovirus': [381], 'expression': [382, 427, 1750, 2679, 2953, 3576], 'system': [383, 3841], 'decoy': [386], 'families': [389], 'ligands.': [392], 'Administration': [393, 494], 'sRAGE': [395, 496, 511, 604, 796, 815, 835, 909, 933, 960, 970, 981, 1023, 1039, 1190, 1273, 1325, 1343, 1376, 1498, 1875, 1937, 1953, 2006, 2040, 2055, 2063, 2123, 2142, 2166, 2177, 3378], 'suppressed': [401, 505], 'early': [402], 'acceleration': [403], 'well': [407, 567], 'prevented': [409], 'progression': [410, 2823], 'disease': [412, 819, 919, 1315, 1384, 1504, 1609, 1730, 1884, 2046, 2871, 3047, 3205], 'established': [417, 503, 2628], 'atherosclerosis.6–7': [418], 'parallel,': [420], 'significantly': [424, 639, 1329, 2187], 'decreased': [425, 527, 640, 1643], 'vascular': [426, 446, 1558, 1823, 1844, 2073, 2922, 2933], 'adhesion': [429, 2085], 'molecules,': [430, 2086], 'prothrombotic': [431, 1790], 'species': [432, 865, 914], 'factor,': [436], 'diminished': [438, 521], 'antigen/activity': [439], 'matrix': [441], 'metalloproteinases': [442], '(MMPs).': [443], 'addition,': [445], 'levels': [447, 738, 794, 813, 833, 907, 958, 1259, 1271, 1295, 1326, 1374, 1496, 1873, 1938, 2061, 2078, 2164, 2859, 3706], 'phosphorylated': [449], 'p38': [450], 'MAP': [451], 'kinase': [452], 'activated': [454], 'NF-κB,': [455], 'key': [457, 2025], 'signaling': [458, 2467, 3738], 'molecule': [459], 'transcription': [461], 'factor': [462, 1131, 1265, 1455, 1715, 2682, 2824], 'linked': [463, 1419, 2153], 'response,': [467], 'respectively,': [468, 1336], 'were': [469, 487, 546, 589, 797, 859, 1327], 'reduced': [470, 1495], 'sRAGE-treated': [472], 'mice.7–8': [473], 'Importantly,': [474], 'these': [475, 544, 649, 788, 1078, 1140, 1184, 1235, 1625, 1668, 1795, 1870, 1930, 2193, 2230], 'provided': [477], 'clue': [480], 'RAGE-dependent': [482, 2778], 'tissue-perturbation': [485], 'not': [488, 547, 921, 943, 962, 1076, 1143, 1439, 3199], 'limited': [489, 548, 2188], 'state.': [493, 552], 'euglycemic': [498, 560], 'progression.7In': [506], 'other': [507, 1098, 1654, 1846, 2028, 2066, 2150], 'studies,': [508, 1687], 'administration': [509, 2175], 'rats': [514, 2181, 3708], 'subjected': [515], 'carotid': [517], 'artery': [518, 558, 804, 818, 1281, 1314, 1383, 1503, 1683, 1883, 1945, 2870, 3083, 3204], 'balloon': [519], 'injury': [520, 611], 'parallel': [525, 747, 1747], 'proliferation': [528], 'smooth': [530, 635, 1102, 1160], 'muscle': [531, 636, 1103, 1161], 'cells': [532, 637, 1086, 1099, 1104, 1108, 1162, 1166, 2924], 'expanding': [535], 'neointima.9': [536], 'As': [537], 'lipid-driven': [542], 'atherosclerosis,': [543, 706, 1647], 'findings': [545, 1245, 1669, 2109], 'Acute': [553], 'denudation': [554], 'femoral': [557], 'C57BL/6': [561], 'rapidly': [563], 'upregulated': [564], 'injured': [575, 646], 'vessel': [576], 'wall,': [577], 'AGEs': [580, 1411], 'S100/calgranulins.10': [582], 'Key': [583, 1112], 'roles': [584, 1113, 2026, 2930], 'ligand–RAGE': [587, 659, 1810], 'axis': [588, 660, 1549, 1811, 1842, 3962], 'shown': [590, 1536], 'suppression': [592], 'expansion': [595, 2186], 'sRAGE.': [600, 1002, 1013, 1150, 1178], 'The': [601, 810, 843, 1059, 1345, 1476, 2195, 2224, 2541, 2818, 3034, 3181, 3418, 3532, 4058], 'target': [602], 'indeed': [606], 'arterial': [610, 2736], 'wild-type': [613], 'treated': [615], 'antibodies': [617, 852, 1218], 'homozygous': [621], 'RAGE-null': [622], 'mice,': [623, 3388, 3580], 'transgenic': [626], 'expressing': [628], 'mutant': [631], 'specifically': [633], 'compared': [641], 'vehicle-treated': [643], 'animals': [644], 'littermates.10Taken': [647], 'indicate': [651], 'models,': [655], 'upregulation': [656, 1136, 1421, 1545, 1786, 1807], 'contributed': [661], 'glucose-,': [663], 'lipid-': [664], 'stress–induced': [667], 'expansion.From': [669], 'Rodents': [670], 'Humans?Evidence': [672], 'accruing': [674], 'right': [680], 'place': [681], 'time': [683], 'contribute': [685, 1528], 'restenosis': [689, 2191], 'human': [691, 705, 775, 1612, 1887, 2013, 2172, 2218, 2832, 2921, 3005], 'subjects.': [692, 1888], 'Cipollone': [693, 2788], 'colleagues': [695, 766, 1065, 1215, 1252, 1481, 1900, 2113, 2203], 'showed': [696], 'expressed': [700, 2919], 'nondiabetic': [702, 1269, 1691, 1886, 2873, 3157], 'enhanced': [709, 800, 1736, 2678], 'degrees': [710, 1606], 'diabetes.': [712, 1630, 2018, 3212], 'Further,': [713, 952, 2019], 'colocalized': [715], 'cox-2,': [717], 'type': [718, 3049, 3210, 3967, 4034], '1/type': [719], '2': [720, 2017, 3211, 3968, 4035], 'microsomal': [721], 'prostaglandin': [722], '(PG)': [723], 'E2,': [724], 'MMPs': [726], 'atherosclerotic': [730, 2833], 'plaques.11': [731], 'When': [732], 'semi-quantified': [733], 'Western': [736], 'blot,': [737], 'plaques': [744], 'rose': [745], 'increase': [750], 'glycosylated': [752], 'hemoglobin,': [753], 'pre-AGE': [754], 'species.11In': [755], 'this': [756, 847, 868, 913, 950, 1067, 1081, 1348, 1561, 1704, 1934, 2105], 'issue': [757, 1068], 'Arteriosclerosis,': [759, 1070, 4128], 'Biology,': [763, 4132], 'Falcone': [764, 1063, 1213, 1250, 1479, 1615, 1898, 1982, 2111, 2201, 2844, 3058, 3093], 'take': [767], 'next': [769, 2057, 2209], 'step': [770], 'linking': [772], 'atherosclerosis.': [776, 3125], 'two': [778, 1653], 'distinct': [779, 1189, 1524, 1620], 'populations': [780], 'age-matched': [782], 'Italian': [783], 'male': [784, 2096], 'subjects': [785, 1291, 1386, 1628, 1634, 2099, 3158], 'without': [786, 1629], 'authors': [789, 858, 1284, 2231, 2264], 'show': [790], 'endogenously': [792], 'lower': [793, 963], 'associated': [798, 1275, 1603, 1968, 1977, 3042], 'risk': [801, 840, 1264, 1531, 1880, 3200, 3231, 3656], 'coronary': [803, 817, 1280, 1313, 1382, 1502, 1646, 1682, 1882, 1944, 2869, 3082, 3124, 3203], 'disease,': [805], 'detected': [807, 866], 'angiography.12': [809], 'link': [811, 1677], 'between': [812, 3073, 3420, 3534], '"dose-dependent,"': [821], 'meticulous': [823], 'statistical': [824, 1355], 'analysis': [825], 'suggested': [826], 'individuals': [828, 1905, 1918], 'very': [831], 'lowest': [832], 'displayed': [836, 1642], 'greatest': [838], 'overall': [839], 'disease.': [842, 1684, 1946, 2513, 3084, 3161], 'chief': [844, 1263], 'limitation': [845], 'study': [848, 1895, 3501], 'generically': [854], 'unable': [860], 'distinguish': [862, 1077], 'whether': [863], 'assay': [869, 1060], 'represented': [870], 'RAGEs,': [872], 'perhaps': [873], 'cleaved/released': [874], 'full-length': [876, 938, 1043, 1571], 'endogenous': [877, 1042, 1129, 2005, 2139, 2246], 'on': [879, 1400, 1906, 3753, 3945, 4180], 'molecules': [884], 'MMPs,': [887], 'novel': [889, 1050, 1575, 1990, 2409, 2553, 2992], 'splice': [890, 1051, 1226, 1576, 2910, 2994], 'variants': [891, 1052, 1227, 1569, 2911], 'RAGE13–15': [893], '(Figure': [894], '1).': [895], 'increased': [897, 1330, 1749], 'diseased': [902, 966], 'milieux': [903], 'might': [904, 934, 1954, 2143], 'suggest': [905, 1589, 1671, 1949], 'directly': [911], 'should': [915], 'higher': [917, 1879, 1941], 'states,': [920], 'lower,': [922], 'our': [923], 'present': [924], 'lack': [925], 'understanding': [927], 'which': [932, 1022], 'does': [942, 1075], 'allow': [944], 'us': [945, 1863], 'make': [947], 'conclusions': [948], 'at': [949, 1579, 1926, 3739], 'time.': [951], 'future': [953, 1998], 'must': [955, 1510, 1829, 2000], 'delineate': [956, 1144], 'are': [961, 1015, 1188, 1418, 1471, 1693, 1732, 2114, 3198], 'population': [967, 3208], 'because': [968], 'binding': [971, 978], 'circulating': [973, 1106, 1164, 2077, 3704], 'ligands,': [974], 'thereby': [975], 'diminishing': [976], 'antibody': [977, 992], 'species.': [982, 2194], 'This': [983], 'possibility': [984, 1509], 'unlikely,': [986], 'however,': [987], 'given': [988, 2020], 'polyclonal': [991], 'included': [994], 'within': [995], 'sandwich': [997], 'ELISA': [998], 'detection': [1000, 1223], 'Download': [1003, 1706], 'figureDownload': [1004, 1707], 'PowerPointFigure': [1005, 1708], '1.': [1006], 'Model': [1007, 3615], 'potential': [1010, 1019, 1700], 'sources': [1011], 'There': [1014], 'number': [1017], 'means': [1020], 'generated.': [1026], 'First,': [1027], 'possible': [1030, 1096, 1158, 1194, 1542, 1566, 2134, 2161], 'yet': [1032], 'delineated': [1035], 'cleave': [1038], 'receptor.': [1046], 'Second,': [1047], 'multiple': [1048, 1726], 'discrete': [1049, 1225], 'generate': [1056, 1110], 'sRAGEs.': [1058, 1111], 'used': [1061], 'Biology': [1074], 'possibilities.': [1079], 'cartoon': [1082], 'suggests': [1083, 1505], 'endothelial': [1085, 1154, 2923], 'principal': [1090], 'source': [1091], 'sRAGE,': [1093, 2243], 'sRAGEs,': [1115], 'decoys': [1117], 'serve': [1125], 'biomarker': [1127, 2244], 'protection': [1130], 'diseases': [1133], 'characterized': [1134, 1733], 'ligands.Furthermore,': [1139], 'do': [1142, 2060], 'specific': [1146, 2952], 'cellular': [1147, 1712], 'source(s)': [1148], 'addition': [1152], 'cells,': [1155], 'monocytes': [1169], 'lymphocytes,': [1171], 'generators': [1176], 'A': [1179, 3461, 3499, 3540], 'further': [1180, 1351, 1772], 'consideration': [1181, 1917], 'arises': [1182], 'possibilities:': [1185], 'if': [1186, 2107], 'there': [1187], 'species,': [1191], 'their': [1196, 2928], 'affinity': [1197], 'differ?': [1205], 'Irrespective': [1206], 'caveats,': [1209], 'work': [1211, 1248, 1980, 2199], 'mandates': [1216], 'corresponding': [1220], 'assays': [1221], 'developed': [1231], 'best': [1233], 'address': [1234, 1698, 2001, 2240], 'hypotheses.RAGE': [1236], 'Lipid': [1239], 'Connection?One': [1240], 'most': [1243], 'intriguing': [1244, 1587], 'even': [1255, 1483], 'after': [1256, 1358], 'correction': [1257, 1359], 'lipids,': [1261], 'driving': [1266], 'subjects,': [1270, 1692, 1912], 'remained': [1274, 1377, 1499], 'disease.12': [1282], 'found': [1285], 'subgroup': [1289], 'LDL': [1293], 'cholesterol': [1294], '<130': [1296], 'mg/dL': [1297], '(3.4': [1298], 'mmol/L),': [1299], 'most-recently': [1301], 'recommended': [1302], 'highly': [1303, 1328], 'stringent': [1304], 'goal': [1305], 'lipid': [1307], 'control,': [1308], 'multivariate-adjusted': [1309], 'odds': [1310], 'ratios': [1311], '(lowest),': [1319], 'second,': [1320], 'third': [1322], 'quartiles': [1323], '10.256,': [1332], '3.005,': [1333], '3.039,': [1335], 'versus': [1337], 'fourth': [1339], '(highest)': [1340], 'quartile': [1341], 'level.12': [1344], 'power': [1346], 'observation': [1349], 'propelled': [1352], 'analyses.': [1356], 'Even': [1357, 1932], 'confounding': [1364], 'factors,': [1365, 1527], 'presumably': [1366], 'factors': [1367, 1674, 3201], 'tobacco': [1370], 'use': [1371], 'hypertension,': [1373], 'an': [1378, 1507, 1661, 3612], 'independent': [1379], 'determinant': [1380], 'among': [1385], 'normal/near': [1388], 'normal': [1389], 'LDL.RAGE': [1390], 'Disease:': [1392], 'Is': [1393, 1513, 2054, 2132, 3881], 'Really': [1395], 'Multiple': [1397], 'Hit': [1398], 'Model?Based': [1399], 'overwhelming': [1401], 'evidence': [1402, 1861], 'S100/calgranulins,': [1414, 1742], 'amphoterin,': [1415, 1743], 'Mac-1': [1417], 'RAGE-related': [1425], 'settings': [1426, 1461, 2043], 'diabetes': [1429, 1448, 2361, 3265, 3459], 'immune/inflammatory': [1431], 'diseases,': [1432, 2030], 'predicted': [1435], 'one': [1440], 'proximate': [1443], 'causes': [1444], 'autoimmunity,': [1450, 1771], 'but,': [1451], 'rather,': [1452], 'magnification': [1454], 'set': [1456, 2233], 'motion': [1458], 'particularly': [1459], 'basal': [1463, 1488, 1544, 1806], 'ligand': [1464], 'accumulation': [1465], 'upregulation.': [1468], 'depicted': [1472], 'Figure': [1474, 1538], '2.': [1475, 1709], 'finding': [1477], 'absence': [1486], 'dysfunction': [1489], 'hyperlipidemia,': [1494, 1768], 'correlated': [1500], 'additional': [1508], 'considered.': [1512], 'plausible': [1515], 'innate': [1517, 1970], 'characteristics': [1518], 'its': [1522, 1574, 2959], 'regulation,': [1523], 'importantly': [1529], 'atherosclerosis?': [1533], '2,': [1539], 'ligand/RAGE': [1548, 2156], 'itself': [1550, 1966], 'sets': [1551, 1985], 'stage': [1553, 1987, 2235], 'development': [1556, 1821], 'inflammation.': [1559], 'alternate': [1562, 1804], 'view,': [1563, 1805], 'forms': [1577, 1847], 'hold,': [1578], 'least,': [1580], 'part': [1581], 'key?': [1584], 'To': [1585], 'date,': [1586], 'particular': [1592, 2225], 'promoter': [1593, 3118], 'allele': [1594], '(−374': [1595], 'A)': [1596], 'gene': [1599, 3039, 3078, 3117, 3187, 3196], 'encoding': [1600], 'lesser': [1605], 'macrovascular': [1608, 1666, 2358, 3160], 'subjects.16–17': [1613], 'colleagues,': [1617], 'report,': [1621], 'recently': [1623], 'extended': [1624], 'observations': [1626], 'They': [1631], 'reported': [1632], '−374': [1637, 3075, 3111, 3185], 'T/A': [1638, 3037, 3076, 3112, 3186], 'A/A': [1640], 'genotypes': [1641], 'severity': [1644, 3122], 'determined': [1649], 'angiography.18': [1651], 'smaller': [1655], 'failed': [1657], 'find': [1659], 'association': [1662, 1877, 3513], 'incidence': [1664, 1942], 'disease,19–20': [1667], 'strongly': [1670], 'indelibly': [1676], 'propensity': [1680], 'Large': [1685], 'scale': [1686], 'especially': [1688], 'those': [1689, 1976, 2033], 'critically': [1694, 1967], 'needed': [1695], 'better': [1697], 'predictive': [1701], 'value': [1702], 'variant.': [1705], 'stress:': [1713], 'initiating': [1714], 'amplifier': [1717], 'injury?': [1723], 'hit': [1727], 'model,': [1728], 'certain': [1729, 1928], 'states': [1731], 'basally': [1735], 'generation': [1737, 1773], '(AGEs,': [1741], 'Mac-1),': [1745], '(hit': [1753, 1758], 'one).': [1754], 'On': [1755], 'superimposed': [1756], 'stresses': [1757], 'two),': [1759], 'infection,': [1762], 'hyperglycemia,': [1765], 'stress,': [1767], 'aging,': [1769], 'activates': [1777], 'via': [1781, 3564], 'pathways.': [1791], 'processes': [1796], 'inflammation': [1798, 1824, 2351, 2676, 3322, 3743], 'destruction.': [1801], 'itself,': [1812], 'single': [1815], 'hit,': [1816], 'contributes': [1817], 'innately': [1818], 'injury.': [1827, 2737, 2934], 'Experiments': [1828], 'performed': [1831], 'dissect': [1833], 'contribution': [1835], 'each': [1837], 'facet': [1838], 'disorders.Soluble': [1850], 'RAGE:': [1851, 2353], 'Biomarker': [1852], 'Endogenous': [1854], 'Protection': [1855], 'Factor?Certainly,': [1856], 'none': [1857], 'available': [1860], 'allows': [1862], 'conclude': [1865], '"cause': [1866], 'effect"': [1868], 'observed': [1871], 'low': [1872, 1936], 'Yet,': [1889], 'attention': [1890], 'criteria': [1893], 'entry': [1896], 'reveals': [1901], 'they': [1903, 1913], 'excluded': [1904], 'lipid-lowering': [1907], 'therapy.': [1908], 'By': [1909, 3288], 'excluding': [1910], 'likely': [1914], 'removed': [1915], 'benefiting': [1919], 'potent': [1922], 'antiinflammatory': [1923], 'effects': [1924], 'least': [1927], 'agents.': [1931], 'setting,': [1935], 'still': [1939], 'reflected': [1940], 'considerations': [1948], 'measurement': [1951, 2038], 'powerful': [1957], 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[2380, 2440, 2452, 2605, 2649, 2716, 3410], 'Avila': [2382], 'Kambham': [2384], 'N,': [2385, 2439, 2524, 2644, 2984, 3176, 3304, 3905, 3907, 3913, 3925], 'Bierhaus': [2386, 2521], 'Nawroth': [2388, 2498, 2539, 2765], 'P,': [2389, 2499, 2948, 3220, 3482, 3486, 3549, 3637, 3641, 3801, 3865], 'Neurath': [2390], 'MF,': [2391], 'Slattery': [2392, 2490], 'T,': [2393, 2449, 2491, 2520, 2530, 2602, 2642, 2646, 2744, 2906, 3403, 3490, 3909, 3915], 'Beach': [2394], 'D,': [2395, 2403, 2503, 2526, 2579, 2754, 2802, 3102, 3256, 3405, 3476], 'McClary': [2396], 'J,': [2397, 2401, 2483, 2495, 2534, 3170, 3248, 3252, 3298, 3332, 3766, 3982, 4164], 'Nagashima': [2398, 2492, 2531], 'M,': [2399, 2451, 2485, 2493, 2532, 2661, 2669, 2752, 2756, 2793, 2795, 2855, 2898, 3026, 3067, 3106, 3308, 3340, 3411, 3484, 3684, 3901, 3923, 4109, 4204], 'Morser': [2400, 2494, 2533], 'Stern': [2402, 2460, 2502, 2578, 2621, 2670, 2718, 2767, 3255], 'mediates': [2407, 2675, 2730], 'axis:': [2411], 'central': [2413, 2775], 'S100/calgranulin': [2418], 'polypeptides.': [2419], 'Cell.': [2420], '1999;': [2421], '97:': [2422], '889–901.CrossrefMedlineGoogle': [2423], 'Scholar3': [2424], 'Blood': [2427], 'DC,': [2428, 2435, 2618], 'del': [2429], 'Toro': [2430], 'G,': [2431, 2501, 2665, 2805, 3592, 3682, 3686, 3688], 'Canet': [2432], 'Lee': [2434, 2570, 2617, 3858, 4161, 4165], 'Tanji': [2438, 2643], 'Lalla': [2442, 2607], 'E,': [2443, 2608, 2847, 3063, 3098, 3492], 'Kislinger': [2448, 2615, 2641], 'Ingram': [2450], 'Tanaka': [2454], 'H,': [2455, 2487, 2884, 2894, 2904, 3639, 4093, 4103], 'Hori': [2456], 'O,': [2457, 3921, 3987], 'Ogawa': [2458], 'DM,': [2461, 2622, 2671, 2719, 2768], 'Blockade': [2464, 3259], 'amphoterin/RAGE': [2466], 'suppresses': [2468], 'tumor': [2469], 'growth': [2470], 'metastases.': [2472], 'Nature.': [2473, 2514], '2000;': [2474], '405:': [2475], '354–360.CrossrefMedlineGoogle': [2476], 'Scholar4': [2477], 'SD,': [2479, 2748], 'Chen': [2480, 2484, 3243, 3303, 3331, 3479], 'X,': [2481, 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