Title: The Clinical Value of Combined Dectection of CA125,CA72-4 and Ferritin in Patients with Ovarian Cancer
Abstract: Objective To investigate the clinic significance of serum levels of CA125,CA72-4 and Ferritin in patients with ovarian cancer.Methods The levels of CA125,CA72-4 and Ferritin in 122 patients with ovarian cancer,in 60 patients with benign ovarian tumor and in 50 healthy controls were measured by electrochemistry lumonescence immunoassay method.Statistical analyses were performed with T test and χ2 test methods.Results The serum levels of CA125,CA72-4 and Ferritin in patients with ovarian cancer were(436.4±137.5) U/ml,(43.2±31.5) U/ml and(1213.5±782.6) ng/ml,respectively,but those with benign ovarian tumor were(62.3±25.6)U/ml,(10.4±4.8) U/ml and(623.4±214.6)ng/ml,respectively,and those healthy controls were 42.5U/ml,(8.8±3.1)U/ml and(544.6±135.4)ng/ml,respectively.The serum levels of CA125,CA72-4 and Ferritin in patients with ovarian cancer were significantly higher than those with benign ovarian tumor(P0.01).Compared with healthy controls patients with benign ovarian tumor have significantly higher levels of CA125,CA72-4 and Ferritin.The positive rates of CA125,CA72-4 and Ferrtin in patients with ovarian cancer were 72.9%,47.5%,and 53.3%,respectively,in patients with benign ovarian tumor were 18.3%,15.0% and 32.0%,respectively and in healthy controls were 2.0%,4.0% and 16.0%,respectively.The positive rate and levels of CA125,CA72-4 and Ferritin were increasing with the clinical stage.Conclusion Combined detection of CA125,CA72-4 and Ferritin can increase the positive detection of ovarian cancer,and thus are helpful in diagnosis of ovarian cancer and compensate the use of only one tumor marker,CA125,for the lower positive rate.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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