Title: Correlation between the expression of survivin and VEGF in HCC and the clinical significance
Abstract: Objective To study the clinical significance of survivin and VEGF in hepatocellular carcinoma (HCC).Methods Expression of survivin and VEGF in 56 HCC patients were assessed by immunohistochemistry staining.Results Survivin and VEGF expression was detected in 34/56 (60.7%),35/56 (62.5%) respectively.The expression rate of survivin was higher in HCC group than that of the adjacent non tumorous liver and the normal liver groups ( P 0.05).There was no significant correlation between the expression of survivin in HCC and the tumor size,capsule status,cirrhosis,the classification of Child Paugh,TNM stage,except the portal vein tumor thrombus ( P 0.05).There was no significant correlation between the expression of VEGF and capsule status,the classification of Child Paugh,cirrhosis.However,the positive rate of VEGF was correlated significantly with tumor size,portal vein tumor thrombus and TNM stage ( P 0.05).There was a close correlation between the expression of survivin and VEGF,proved by the correlation test (χ 2=4.491, P 0.05).Conclusion Survivin and VEGF are over expressed in HCC tissues.The progression of HCC is related to the up regulation of expression of survivin and VEGF.The expression of survivin and VEGF has a close correlation.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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