Title: The expression and clinical significance of Bcl-2,Bax,Fas in extrohepatic cholangiocarcinoma
Abstract: Objective To study the expression and significance of Bcl-2,Bax,Fas in extrohepatic cholangiocarcinoma(ECHC).Methods The expression of Bcl-2,Bax,Fas in 41 cases of ECHC was detected by SP immunohistochemical staining.Results(1)The positive rates of Bcl-2 in well and (mediated-)differentiated group(A),poordifferentiated group(B),nonmetastasis group(C) and metastasis group(D) were 75.00%,23.08%,76.00% and 31.25% respectively.The expression rate of Bcl-2 was significantly related to histopathological grade and metastasis(P0.01).(2)The positive rates of Bax in group A,group B,group C and group D were 67.86%,30.77%,72.00% and 31.25% respectively.The expression rate of Bax was associated with histopathological grade and metastasis((P0.05).)(3)The positive rates of Fas in group A,group B,group C and group D were 67.86%,15.38%,76.00% and 12.50% respectively.The expression rate of Fas was associated with histopathological grade and metastasis(P0.01).Conclusion The abnormal expression of Bcl-2,Bax,Fas is correlated with histopathological grade and metastasis.The expression of the three genes can be used to predict the prognosis of ECHC.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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