Title: Correlation between Bcl-2 and Ki67 in radicular epitheliated granulomas
Abstract: Aim To assess the immunohistochemical expression of wild-type p53, Bcl-2 and Ki67 in the basal layer of proliferating radicular cysts. Methods A histopathological examination revealed the presence of proliferating radicular cysts in 22 specimens. Paraffin-embedded histological slices of these 22 radicular cysts were examined by immunohistochemistry for expression of wild-type p53, Bcl-2 and Ki67 in the basal layer of proliferating radicular cysts. Results A significant correlation was found between Bcl-2 and Ki67 (p < 0.01). Wild-type p53 was found to be positive in all patients, acting as a constant factor. The covariance effect of wild-type p53 on the correlation of Bcl-2 and Ki67 was found to be significant (p < 0.05). Conclusion The correlation of the oncoproteins Bcl-2 and Ki67 may be characterized by their synchronous presence. The basal layer mainly expressed this characteristic, indicating its importance in the regulation of epithelial apoptosis.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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