Title: Giant cell-rich variant of solitary fibrous tumor:a clinicopathologic observation
Abstract: Objective To investigate the clinicopathologic features and differential diagnosis of giant cell-rich variant of solitary fibrous tumors. Methods Routine pathological examinations,immunohistochemical staining of 2 cases of GR-SFT and literature review were performed. The clinical features,pathological changes,immunophenotypes and differential diagnosis of the tumor were summaried in this study. Results Grossly,the tumor mass was well circumscribed. Histologically,there were multinucleated giant cells distributed focally or diffusely on the background of histological changes of solitary fibrous tumors. The shape and distribution of giant cells were characteristic. Giant cells were mainly located in areas with dense collagen deposition and sparseness of mononuclear mesenchymal cells. Tumor cells,including giant cells,expressed CD34,CD99 and Bcl-2. Conclusion Giant cell-rich solitary fibrous tumor is a special variant of solitary fibrous tumors. Patients are mainly adults aged above 40 years,and with a female predominance. The shape,distribution and immunophenotype of giant cells are significant in the pathological diagnosis. The tumor should be distinguished from other benign and malignant soft tissue tumors including giant cell angiofibroma,giant cell fibroblastoma,fibrous histiocytoma,plexiform fibrohistiocytic tumor,giant cell tumor of soft tissue and malignant fibrous hisiocytoma/ undifferentiated sarcoma. The appearance of giant cells probably represents a degenerative phenomenon.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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