Publication Information

{'id': 'https://openalex.org/W2380748750', 'doi': None, 'title': '[Expression of genes related to Sonic Hedgehog signaling in human hepatocellular carcinomas].', 'display_name': '[Expression of genes related to Sonic Hedgehog signaling in human hepatocellular carcinomas].', 'publication_year': 2008, 'publication_date': '2008-12-18', 'ids': {'openalex': 'https://openalex.org/W2380748750', 'mag': '2380748750', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19088834'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19088834', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046126034', 'display_name': 'Li Che', 'orcid': 'https://orcid.org/0000-0001-7971-8725'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4210093964', 'display_name': 'Peking University Cancer Hospital', 'ror': 'https://ror.org/00nyxxr91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093964']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Li Che', 'raw_affiliation_strings': ['Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Medical Oncology, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China.'], 'affiliations': [{'raw_affiliation_string': 'Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Medical Oncology, Beijing Cancer Hospital & Institute, Peking University School of Oncology, Beijing, China.', 'institution_ids': ['https://openalex.org/I20231570', 'https://openalex.org/I4210093964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055794211', 'display_name': 'Jun Ren', 'orcid': 'https://orcid.org/0000-0002-3098-9767'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jun Ren', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101634609', 'display_name': 'Yan Yuan', 'orcid': 'https://orcid.org/0000-0003-2831-6755'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yan Hua Yuan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069860538', 'display_name': 'Jun Jia', 'orcid': 'https://orcid.org/0000-0001-7585-755X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jun Jia', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110966914', 'display_name': 'Li Jun Di', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Li Jun Di', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006470297', 'display_name': 'Guo Hong Song', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Guo Hong Song', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100731459', 'display_name': 'Jing Yu', 'orcid': 'https://orcid.org/0000-0002-6371-3724'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jing Yu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110078893', 'display_name': 'Xiao Li Wang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Xiao Li Wang', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.499251, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 81, 'max': 82}, 'biblio': {'volume': '40', 'issue': '6', 'first_page': '616', 'last_page': '23'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 0.9921, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 0.9921, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hccs', 'display_name': 'HCCS', 'score': 0.9043039}, {'id': 'https://openalex.org/keywords/gli2', 'display_name': 'GLI2', 'score': 0.45898116}, {'id': 'https://openalex.org/keywords/gli1', 'display_name': 'GLI1', 'score': 0.42885277}], 'concepts': [{'id': 'https://openalex.org/C2779314089', 'wikidata': 'https://www.wikidata.org/wiki/Q18026830', 'display_name': 'HCCS', 'level': 3, 'score': 0.9043039}, {'id': 'https://openalex.org/C88498014', 'wikidata': 'https://www.wikidata.org/wiki/Q14859918', 'display_name': 'Hedgehog signaling pathway', 'level': 3, 'score': 0.8775589}, {'id': 'https://openalex.org/C2776637008', 'wikidata': 'https://www.wikidata.org/wiki/Q14860072', 'display_name': 'Sonic hedgehog', 'level': 3, 'score': 0.87485147}, {'id': 'https://openalex.org/C2778539099', 'wikidata': 'https://www.wikidata.org/wiki/Q6120', 'display_name': 'Hedgehog', 'level': 3, 'score': 0.8349254}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5951204}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5798974}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.50607055}, {'id': 'https://openalex.org/C120407494', 'wikidata': 'https://www.wikidata.org/wiki/Q14886491', 'display_name': 'GLI2', 'level': 4, 'score': 0.45898116}, {'id': 'https://openalex.org/C2778019345', 'wikidata': 'https://www.wikidata.org/wiki/Q1148337', 'display_name': 'Hepatocellular carcinoma', 'level': 2, 'score': 0.43251112}, {'id': 'https://openalex.org/C2779933373', 'wikidata': 'https://www.wikidata.org/wiki/Q14886430', 'display_name': 'GLI1', 'level': 4, 'score': 0.42885277}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.37322888}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.16417149}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.11431199}], 'mesh': [{'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006528', 'descriptor_name': 'Carcinoma, Hepatocellular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008113', 'descriptor_name': 'Liver Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011379', 'descriptor_name': 'Prognosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19088834', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W94167612', 'https://openalex.org/W3103278474', 'https://openalex.org/W2386900985', 'https://openalex.org/W2379954191', 'https://openalex.org/W2353020559', 'https://openalex.org/W2171103892', 'https://openalex.org/W2155068099', 'https://openalex.org/W2138258108', 'https://openalex.org/W2128670495', 'https://openalex.org/W2113756471', 'https://openalex.org/W2086177031', 'https://openalex.org/W2084381245', 'https://openalex.org/W2055432536', 'https://openalex.org/W2046465935', 'https://openalex.org/W1997560595', 'https://openalex.org/W1990036024', 'https://openalex.org/W1980947199', 'https://openalex.org/W1969050050', 'https://openalex.org/W1919928872', 'https://openalex.org/W1602655680'], 'abstract_inverted_index': {'To': [0], 'investigate': [1], 'the': [2, 19, 39, 56, 92, 125, 129, 157, 177, 209], 'expression': [3, 40, 57, 167], 'status': [4], 'of': [5, 41, 58, 66, 83, 94, 102, 124, 131, 143, 168, 193, 211], 'Sonic': [6], 'Hedgehog': [7], 'signaling': [8, 43, 60, 185, 203], 'genes': [9, 23, 44, 110], 'and': [10, 16, 24, 28, 54, 85, 113, 122, 128, 133, 145, 152, 172], 'molecules': [11, 61], 'in': [12, 80, 86, 99, 118, 136, 148, 163, 170], 'human': [13, 194], 'hepatocellular': [14], 'carcinomas(HCC),': [15], 'to': [17, 91, 176], 'explore': [18], 'relationship': [20, 181], 'between': [21], 'these': [22], 'clinical': [25], 'prognosis.HCC': [26], 'tissue': [27, 31], 'adjacent': [29, 90, 175], 'normal': [30], 'from': [32], '29': [33, 81, 87], 'HCC': [34, 84, 137, 171], 'patients': [35], 'were': [36, 72, 116], 'assayed': [37, 73], 'for': [38, 55, 191, 201, 208], 'hedgehog': [42, 59, 108, 158, 202], 'by': [45, 62], 'reverse': [46], 'transcription-polymerase': [47], 'chain': [48, 50], 'reaction': [49, 51], '(RT-PCR)': [52], 'techniques': [53], 'immunohistochemistry.': [63], 'The': [64, 165], 'expressions': [65, 130], 'Shh,': [67, 77], 'Ptch,': [68, 111], 'Smoh,': [69], 'Gli-1': [70, 114, 169], 'mRNA': [71, 96, 115, 147], 'as': [74, 76], 'well': [75], 'Ptch': [78, 134, 146], 'proteins': [79, 135], 'cases': [82], 'liver': [88, 173], 'tissues': [89, 139, 150, 174], 'tumor.Expression': [93], 'Shh': [95, 132, 144], 'was': [97, 160], 'detectable': [98], 'about': [100], '51%': [101], 'HCCs': [103], 'examined.': [104], 'Consistent': [105], 'with': [106, 141, 182], 'this,': [107], 'target': [109], 'Smoh': [112], 'expressed': [117], 'over': [119], '68%,': [120], '48%': [121], '62%': [123], 'tumors,': [126], 'respectively,': [127], 'tumor': [138, 149, 178], 'correlated': [140], 'those': [142], '(P=0.041': [151], 'P=0.035).': [153], 'This': [154], 'suggested': [155], 'that': [156, 199], 'pathway': [159], 'frequently': [161], 'activated': [162], 'HCCs.': [164, 195], 'simultaneous': [166], 'had': [179], 'significantly': [180], 'poor': [183], 'prognosis.Hedgehog': [184], 'activation': [186, 204], 'is': [187], 'an': [188], 'important': [189], 'event': [190], 'development': [192], 'It': [196], 'also': [197], 'suggests': [198], 'markers': [200], 'may': [205], 'be': [206], 'useful': [207], 'determination': [210], 'prognosis.': [212]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2380748750', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-15T21:41:47.308168', 'created_date': '2016-06-24'}