Title: Structure Elucidation of Androstan Intermediate in the Synthesis of Vecuronium Bromide
Abstract: 2β,16β-dipieridino-5α-androstan-3α,17β-diol is an important intermediate in the synthesis of vecuronium bromide.In this study,the molecular structure of the compound was elucidated by MS,IR,1D NMR and 2D NMR techniques(i.e.,1H NMR,13C NMR,DEPT,1H-1H COSY,HSQC and HMBC).The stereochemistry conformation of the compound was confirmed by ROESY experiments.The 13C NMR chemical shifts of five other androstan intermediates were also assigned.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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