Title: Synthesis and NMR Characterization of a New Coumarin-7,8-cyclophosphoramide Derivative
Abstract: The Mannich reaction was used to aminomethylate 7-hydroxycoumarin selectively at the 8-C position.The product,8-(N-alkylaminomethyl) coumarin,was then coupled with bis-β-chloroethyl dichlorophosphamide to form a novel coumarin-7,8-cyclophosphoramide derivative via the cyclized reaction.The intermediate and the product were analyzed by NMR spectroscopy.The results confirmed the reaction pathway.The structure of the final product was elucidated by DEPT and 2D NMR techniques including 1H-1H COSY,HSQC and HMBC.All 1H and 13C NMR chemical shifts of the title compound were assigned.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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