Title: Study on Pharmacokinetics of Syringopicroside in Rabbits
Abstract: Objective:To identify pharmacokinetics of syringopicroside in rabbits.Methods:The plasma samples were collected after intravenous injection and syringopicroside was determined by HPLC after solid-phase extraction.The data were analyzed with software Multi97 and the pharmacokinetic parameters were calculated.Results:Two compartment model was shown after syringopicroside administration.The main pharmacokinetic parameters are presented respectively: T_(1/2(α))=2.655 min,T_(1/2(β))=16.54 min,AUC=272.32 μg·mL~(-1)·min,CL=(0.037 1 mL·min~(-1)),K_(12)=(0.090 8 min~(-1)),K_(21)=0.124 min~(-1).Conclusion:The pharmacokinetics of syringopicroside showed a rapid distribution,the elimination was also fast,and the retention time was short.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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