Title: The relationship of vascular endothelial growth factor-C and C-C chemokine receptor 7 expressions with lymphatic metastasis and prognosis of human malignant melanoma
Abstract: Objective To study the relationship of vascular endothelial growth factor-c(VEGF-C) and C-C chemokine receptor 7(CCR7) expressions with lymphatic invasion, lymph node metastasis and the prognosis in malignant melanoma. Methods Expressions of VEGF-C and CCR7 were immunohistochemically evaluated in 56 malignant melanoma patients.LYVE-1 was selected as a lymphatic endothelial cell marker. Survival was analyzed by the Kaplan–Meier method. Indicators related to the prognosis of malignant melanoma were screened using Cox's proportional hazards models. Results The expressions of both VEGF-C and CCR7 are detected in the cytoplasm of the malignant cells. CCR7 expression was positively correlated to the expression of VEGF-C and lymphatic invasion, CCR7 and VEGF-C synergistically enhanced lymphatic invasion, but no correlation between CCR7 expression and lymph node metastasis. Conclusion CCR7 and VEGF-C might be involved in tumor lymphatic invasion,simultaneously, but CCR7 and lymphatic invasion could not be markers for evaluation of clinical prognosis in patients with malignant melanoma.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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