Title: The value of serum β_2 microglobulin in the prediction of children renal disease
Abstract: Objective To investigate the clinical significance of serum and urinary β2 microglobulin(β2-MG) in the early diagnosis of children kidney disease.Methods The blood,urinary β2-MG levels in 50 children with kidney disease were tested by radioimmunoassay in the meantime,serum creatinine(Cr) and urea nitrogen(BUN) were tested as well.35 healthy children were chosen as the control group.Results The blood,urinary β2-MG were significantly higher in the experimental group(P0.01).There was also a significant difference between severe kidney disease group and mild disease group(P0.05).The abnormal rate(80%) of increasing nephrotic syndrome serum β2-MG,which was obviously higher than the abnormal rate of blood Cr(12%) and BUN(18%).Conclusion The serum β2-MG levels can be used as an more important indicator of renal damage than BUN,and Cr can be an early reflection of the determination of renal function,the joint determination of blood,urine β2-MG.Conventional biochemical indicators of renal function on the diagnosis accuracy has important clinical value.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot