Title: Progress in research on small molecular inhibitors of Hedgehog signal pathway
Abstract: The Hedgehog signal pathway exists in human and is involved in the embyrogenesis. It is quiescent in adults except for tissue maintenance and repair. Abnormal activation of the Hedgehog signaling pathway has been linked to several human solid tumors,such as basal cell carcinomas,medulloblastoma,breast carcinoma,colorectal carcinoma,ovarian cancer,and prostate cancer. In addition to cyclopamine and its derivatives,some small molecular inhibitors of Hedgehog signal pathway has been discovered. Hedgehog signal pathway has been demonstrated to be a useful target for drug discovery especially GDC-0449 was proved by FDA in 2012 for the treatment of BCCs. In this review,we provided an overview of the structure information and molecular action mechanisms of small molecular inhibitors of Hedgehog signal pathway.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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