Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1994634298', 'doi': 'https://doi.org/10.1007/s12272-012-0801-8', 'title': 'Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer', 'display_name': 'Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer', 'publication_year': 2012, 'publication_date': '2012-08-01', 'ids': {'openalex': 'https://openalex.org/W1994634298', 'doi': 'https://doi.org/10.1007/s12272-012-0801-8', 'mag': '1994634298', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22941475'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s12272-012-0801-8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119001223', 'display_name': 'Archives of Pharmacal Research', 'issn_l': '0253-6269', 'issn': ['0253-6269', '1976-3786'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5088518056', 'display_name': 'Jeong In Yun', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210151417', 'display_name': 'Korea Research Institute of Chemical Technology', 'ror': 'https://ror.org/043k4kk20', 'country_code': 'KR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210151417']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jeong In Yun', 'raw_affiliation_strings': ['Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Deajeon, 305-600, Korea.'], 'affiliations': [{'raw_affiliation_string': 'Division of Drug Discovery Research, Korea Research Institute of Chemical Technology, Deajeon, 305-600, Korea.', 'institution_ids': ['https://openalex.org/I4210151417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085722499', 'display_name': 'Hyoung Rae Kim', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hyoung Rae Kim', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066696265', 'display_name': 'Haeil Park', 'orcid': 'https://orcid.org/0000-0002-1092-0607'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Haeil Park', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026715008', 'display_name': 'Sang Kyum Kim', 'orcid': 'https://orcid.org/0000-0001-5769-0792'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sang Kyum Kim', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039379192', 'display_name': 'Jong‐Kook Lee', 'orcid': 'https://orcid.org/0000-0003-0739-7963'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jongkook Lee', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3490, 'currency': 'EUR', 'value_usd': 4590, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.825, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 35, 'citation_normalized_percentile': {'value': 0.303435, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '35', 'issue': '8', 'first_page': '1317', 'last_page': '1333'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling in Development and Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling in Development and Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetic Modifications and Their Functional Implications', 'score': 0.9311, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9245, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/smoothened', 'display_name': 'Smoothened', 'score': 0.64742994}, {'id': 'https://openalex.org/keywords/hedgehog-signaling', 'display_name': 'Hedgehog Signaling', 'score': 0.572799}, {'id': 'https://openalex.org/keywords/cancer-therapy', 'display_name': 'Cancer Therapy', 'score': 0.526446}, {'id': 'https://openalex.org/keywords/tumor-suppression', 'display_name': 'Tumor Suppression', 'score': 0.511982}, {'id': 'https://openalex.org/keywords/vismodegib', 'display_name': 'Vismodegib', 'score': 0.4225037}], 'concepts': [{'id': 'https://openalex.org/C88498014', 'wikidata': 'https://www.wikidata.org/wiki/Q14859918', 'display_name': 'Hedgehog signaling pathway', 'level': 3, 'score': 0.8661971}, {'id': 'https://openalex.org/C2778539099', 'wikidata': 'https://www.wikidata.org/wiki/Q6120', 'display_name': 'Hedgehog', 'level': 3, 'score': 0.8550235}, {'id': 'https://openalex.org/C145837895', 'wikidata': 'https://www.wikidata.org/wiki/Q18031607', 'display_name': 'Smoothened', 'level': 4, 'score': 0.64742994}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5147186}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.50179505}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.4996705}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.4583338}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.4344913}, {'id': 'https://openalex.org/C2779545874', 'wikidata': 'https://www.wikidata.org/wiki/Q2070286', 'display_name': 'Vismodegib', 'level': 4, 'score': 0.4225037}, {'id': 'https://openalex.org/C2778804307', 'wikidata': 'https://www.wikidata.org/wiki/Q809758', 'display_name': 'Basal cell carcinoma', 'level': 3, 'score': 0.42141697}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3540055}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.30562124}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2729059}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.14657998}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.10279}, {'id': 'https://openalex.org/C3019992690', 'wikidata': 'https://www.wikidata.org/wiki/Q92767510', 'display_name': 'Basal cell', 'level': 2, 'score': 0.094347715}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002986', 'descriptor_name': 'Clinical Trials as Topic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004353', 'descriptor_name': 'Drug Evaluation, Preclinical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053823', 'descriptor_name': 'Hedgehog Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072086', 'descriptor_name': 'Smoothened Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s12272-012-0801-8', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S119001223', 'display_name': 'Archives of Pharmacal Research', 'issn_l': '0253-6269', 'issn': ['0253-6269', '1976-3786'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22941475', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.74, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 94, 'referenced_works': ['https://openalex.org/W1963493384', 'https://openalex.org/W1963622606', 'https://openalex.org/W1965431780', 'https://openalex.org/W1976551834', 'https://openalex.org/W1979104257', 'https://openalex.org/W1979837082', 'https://openalex.org/W1984627030', 'https://openalex.org/W1984999562', 'https://openalex.org/W1985585069', 'https://openalex.org/W1985795036', 'https://openalex.org/W1992865216', 'https://openalex.org/W1996162154', 'https://openalex.org/W2000572318', 'https://openalex.org/W2000827581', 'https://openalex.org/W2001547088', 'https://openalex.org/W2002249795', 'https://openalex.org/W2006231917', 'https://openalex.org/W2010237337', 'https://openalex.org/W2010515415', 'https://openalex.org/W2014060948', 'https://openalex.org/W2016986240', 'https://openalex.org/W2017204222', 'https://openalex.org/W2020131167', 'https://openalex.org/W2020968277', 'https://openalex.org/W2025743781', 'https://openalex.org/W2026379260', 'https://openalex.org/W2027034464', 'https://openalex.org/W2028755174', 'https://openalex.org/W2030943228', 'https://openalex.org/W2032904555', 'https://openalex.org/W2039696147', 'https://openalex.org/W2041723754', 'https://openalex.org/W2045204046', 'https://openalex.org/W2050569781', 'https://openalex.org/W2056041663', 'https://openalex.org/W2057671045', 'https://openalex.org/W2063266633', 'https://openalex.org/W2064938010', 'https://openalex.org/W2072838176', 'https://openalex.org/W2074466372', 'https://openalex.org/W2076389391', 'https://openalex.org/W2077802746', 'https://openalex.org/W2079682684', 'https://openalex.org/W2081170157', 'https://openalex.org/W2082128755', 'https://openalex.org/W2082618851', 'https://openalex.org/W2087812914', 'https://openalex.org/W2087896991', 'https://openalex.org/W2088767499', 'https://openalex.org/W2088811912', 'https://openalex.org/W2090455515', 'https://openalex.org/W2093578888', 'https://openalex.org/W2093659327', 'https://openalex.org/W2094123668', 'https://openalex.org/W2095818182', 'https://openalex.org/W2097083972', 'https://openalex.org/W2098176608', 'https://openalex.org/W2099423504', 'https://openalex.org/W2101764592', 'https://openalex.org/W2105785824', 'https://openalex.org/W2107441200', 'https://openalex.org/W2108707301', 'https://openalex.org/W2108969421', 'https://openalex.org/W2110321605', 'https://openalex.org/W2111279921', 'https://openalex.org/W2111630048', 'https://openalex.org/W2111826622', 'https://openalex.org/W2114455979', 'https://openalex.org/W2115399432', 'https://openalex.org/W2118966275', 'https://openalex.org/W2121017846', 'https://openalex.org/W2123600514', 'https://openalex.org/W2124539257', 'https://openalex.org/W2124541081', 'https://openalex.org/W2127168458', 'https://openalex.org/W2128670495', 'https://openalex.org/W2128801071', 'https://openalex.org/W2139499843', 'https://openalex.org/W2140350596', 'https://openalex.org/W2142159058', 'https://openalex.org/W2146196731', 'https://openalex.org/W2153260902', 'https://openalex.org/W2156416422', 'https://openalex.org/W2161121683', 'https://openalex.org/W2161622432', 'https://openalex.org/W2164642954', 'https://openalex.org/W2166221624', 'https://openalex.org/W2167366196', 'https://openalex.org/W2312533379', 'https://openalex.org/W2339924084', 'https://openalex.org/W2474599166', 'https://openalex.org/W2526421941', 'https://openalex.org/W397032357', 'https://openalex.org/W4247150858'], 'related_works': ['https://openalex.org/W90736730', 'https://openalex.org/W4304804698', 'https://openalex.org/W4245076447', 'https://openalex.org/W3002730254', 'https://openalex.org/W2282601220', 'https://openalex.org/W2110135410', 'https://openalex.org/W2090858', 'https://openalex.org/W2023796095', 'https://openalex.org/W1970915933', 'https://openalex.org/W1829157304'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1994634298', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 6}], 'updated_date': '2024-09-19T23:16:54.003973', 'created_date': '2016-06-24'}