Title: The local treatment effects of minocycline hydrochloride ointment to adult periodontitis
Abstract: Objective To evaluate the effects of minocycline hydrochloride ointment on adult periodontitis treatment. Methods Thirty patients with chronic periodontitis with a total of 80 teeth were included in the study. After scaling and root planing, one side each patients teeth was assigned as an experimental group and treated with minocycline hydrochloride ointment. The other side of the patients teeth was assigned as a control group and treated with metronidazoe stilus. For both group, the following indexes were recorded at the baseline, 8 weeks, and 16 weeks after the treatment: plaque index (PLI), sulcus bleeding index (SBI), probing depth (PD) , and clinical attachment loss (CAL) . Results At the baseline, there was no significant difference in the indexes between the two groups. At 8 and 16 weeks after the treatment, both groups showed significant improvement in their examined indexes. At 8 weeks, the PLI and the PD scores were significantly lower in the experimental group than that in the control group. There was no significant difference in the SBI scores between the two groups. At 16 weeks, all of the clinical indexes were significantly lower than the experimental group. Conclusion Local drug delivery of minocycline hydrochloride can effectively treat chronic periodontitis and is more effective than the metronidazoe.
Publication Year: 2005
Publication Date: 2005-01-01
Language: en
Type: article
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