Title: Relationship between HER-2/neu Gene and HBsAg
Abstract: Objective: To investigate the expressions of HER-2/neu,HBsAg and HBcAg by SP reagents in 45 patients with hepatocellular carcinoma(HCC). Methods: All samples from HCC were immunohistochemically examined by SP reagents. Results: The expressions of HER-2/neu gene and HBsAg in HCC were significantly lower than those para-cancerous tissues (χ2 = 22.77,χ2 = 15.65,P 0.01). There was no significant difference for expression of HBcAg in HCC and para-cancerous tissues(χ2 = 2.70,P 0.05). HER-2/neu gene was positively related with HBsAg and HBcAg (χ2=17.78,r=0.532 and χ2=8.46,r=0.398). In the positive group of HER-2/neu, the expressions of HBsAg and HBcAg were significant higher than those of the negative group(χ2=12.69, P 0.01and χ2=5.08,P 0.05). Howerer para-cancerous tissues was positively related with HBsAg (χ2 = 15.33,r = 0.254) and was not related with HBcAg (χ2 = 0.126 7,P 0.05). In the positive group of HER-2/neu, the expressions of HBsAg in para-cancerous tissues were higher than those of the negative group (χ2=11.84,P 0.05). There were no significant differences in the expressions of HER-2/neu between Ⅰ+Ⅱgroup and Ⅲ+Ⅳgroup for the clinical classification (χ2=0.95,P 0.05). Conclusion: When the expression of HER-2 /neu gene was observed, the positive rate of HBsAg and HBcAg was both increased. With the stage of HCC in clinical stage, the expression of HER-2/neu gene inclined to decrease in para-cancerous tissues.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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