Title: Expressions and clinical significance of COX-2,p53 and PCNA in patients with esophageal carcinoma
Abstract: Objective To explore the expressions of cyclooxygenase 2(COX-2),p53 gene and proliferating cell nuclear antigen(PCNA) in patients with esophageal cancer and their association with tumor differentiation degree and clinical staging.Methods Forty-nine patients with esophageal carcinoma admitted from March 2009 to April 2013 were recruited.The samples of tumor tissues and para-cancer tissues were taken in performing operation.The levels of COX-2,p53 and PCNA in samples were all detected,and the relationship between expression levels and clinical features was analyzed.Results The positive rate of COX-2 in low-differentiation tumor tissues was significantly higher than that in high-differentiation tumor tissues(P 0.05).According to TNM staging of tumor tissues,the positive rates of COX-2 in 0 ~ Ⅱphases were significantly lower than those in Ⅲ ~ Ⅳphases(P 0.05).The positive rates of COX-2,p53 and PCNA in cancer tissues were all higher than those in para-cancer tissues(all P 0.05).Conclusions COX-2,p53 and PCNA in cancer tissues of patients with esophageal cancer present overexpression,and this has a certain value for judging malignant degree of esophageal carcinoma.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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