Title: Observation the effects of different dose dexmedetomidine to the anesthesia induction of off-pump coronary artery bypass grafting
Abstract: Objective: To observe the sedative effects and hemodynamic changes after the use of different dose dexmedetomidine during the anesthesia induction of off-pump coronary artery bypass graft(CABG).Methods: Sixty ASAⅡ patients undergoing off-pump CABG were randomly divided into three groups,each group was given either 0.5 μg/kg(group D5,n=20),or 0.7μg/kg(group D7,n=20),or 1 μg/kg(group D1,n=20) dexmedetomidine by way of intravenous infusion before anesthesia induction.The Ramsay's value were recorded when the patients entered the room(base value) and after dexmedetomidine infusion.The BIS's value,HR and SBP were recorded at the time points of room enter(base value,T0),end of dexmedetomidine infusion(T1),before endotracheal intubation(T2),just after endotracheal intubation(T3),and 10min after intubation.Results: The Ramsay's value after dexmedetomidine infusion was significantly higher than base value in each group(P0.05).Either of the BIS,HR and SBP had a decreasing tendency in each group from the T1 time point.In group D5,the HR and SBP were significantly higher at T3 time point than T2(P0.05),and the BIS showed an obvious recovery at T4 point.The BIS,HR and SBP in Both of group D7 and D1 had no changes at the T2,T3 and T4 points.In group comparison,the reduction of BIS,HR and SBP had the most degrees compared to the other two groups.And the P value was less than 0.05 to each group D5 or D7.Conclusion: Giving 0.7 μg/kg dexmedetomidine before anesthesia induction by way of intravenous infusion may be more favorable to patients undergoing off-pump CABG.
Publication Year: 2013
Publication Date: 2013-01-01
Language: en
Type: article
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