Title: Dıfferent Doses Of Dexmedetomidine On Controllıng Haemodynamıc Responses To Tracheal Intubatıon
Abstract: Study ObjectiveTo compare the clinical effects of two different doses of dexmedetomidine on haemodynamic responses to tracheal intubation and quality of intubation.DesignDouble-blinded, randomized study.SettingOperating room.Patients60 ASA physical status I and II patients scheduled for elective gynecologic surgery.InterventionsGroup I patients received 1.0 μg.kg in 10 min and group II patients received 0.5 μg.kg dexmedetomidine in 5 min respectively. 90 sec after infusion, thiopental sodium 5 μg.kg and vecuronium bromide 0.1 μg.kg were administered for induction. Intubation was performed after 90 sec.MeasurementsMeasurements of systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR) and O2 saturation (SpO2) were performed at baseline (t) 60 sec after dexmedetomidine infusion (t1), 60 sec after induction (t2), 60 sec after intubation (t3), 5 min after intubation (t4). Quality of intubation was assessed according to Modified McNeil Scoring System.Main ResultsSBP, DBP, MAP values were significantly lower at t3 period in group I than group II (p 0.05). SpO2 values were significantly lower at t1 period in group I than in group II ( p 0.05). SpO2 values were significantly lower at t1 period in group I than in group II ( p<0.05). There was no difference between the groups with respect to the quality scores of tracheal intubation, position of the vocal cords, jaw relaxation and movement of the limbs.ConclusionDexmedetomidine 1 μg.kg was found more effective than dexmedetomidine 0.5 μg.kg in controlling haemodynamic responses to tracheal intubation.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 19
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