Title: Recent advances in study on the role of NPY in pain modulation
Abstract:Neuropeptide Y ( NPY ) is one of the most abundant neuropeptides in the central nervous system (CNS), which is involved in lots of physiological actions. Recently, there are many articles about NPY ta...Neuropeptide Y ( NPY ) is one of the most abundant neuropeptides in the central nervous system (CNS), which is involved in lots of physiological actions. Recently, there are many articles about NPY targeting its roles in pain modulation by means of different animal models. It is shown that the analgesic effect could be induced by either activating the Y1 receptor locating in the CNS or inhibiting the Y2 receptor in the DRG. These studies would provide important rationale for development and application of new type analgesic drugs aiming directly at Y1/Y2 receptor. This review will summarize the roles of NPY in pain processing and related mechanisms in these researches.Read More
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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