Title: The Neuron-protective Effect of Promethazine on Local Cerebral Ischemia Injury in Rats
Abstract: Objective: To observe the effect of promethazine on local cerebral ischemia injury in rats.Methods: Modified Longa's method was used to make rats'models with reversible middle cerebral artery occlusion(MCAO).Rats were randomly divided into 5 control groups(reperfusion for one hour、6 hours、one day、3 and 7 days following MCAO for 2 hours)and 5 promethazine groups with the same time point,then the infarction volume was measured and the neurologic dysfunction was scored.Results: Rats with infarctions and disorders in neurological function one day after IR.Scores and volume of infarctions reduced significantly in promethazine groups(P0.05).Conclusion: Promethazine can prevent the injury of neuron after local cerebral ischemia in rats and produce the neuron-protective effects.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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