Title: Protective effects of cycolsporin A on cerebral ischemia reperfu-sion injury in rats
Abstract: Aim: To investigate the neuroprotective effects of cycolsporin A after focal cerebral ischemia reperfu-sion injury. Methods: Reversible middle cerebral artery occlusion(MCAO) was induced 1 h after ischemia. The rats used to determine the infarction region of cerebral injury were randomly allocated into 3 groups: MCAO-treatment group, MCAO-nontreatment group, and control group (no injury, no treatment). The rats used to calculate brain water content were randomly allocated into 2 groups: MCAO-treatment group and MCAO-nontreatment group. Infarction region was measured with TTC staining 1 d after ischemia. Brain water content was estimated 2 d after ischemia. Results: Compared with control group, the infarction region decreased (P10. 01), and brain edema in MCAO-treatment group ameliorated(P0. 01). Conclusion: Cycolsporin A has obvious protective effects on cerebral ischemia reperfusion injury in rats.
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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