Title: Clinical and pathological observation on primary pulmonary primitive neuroectodermal tumor
Abstract: Objective Primitive neuroectodermal tumor( PNET) is a rare malignant small round cell tumor. This paper aimed to study the clinical and pathological features of primary pulmonary primitive neuroectodermal tumor. Methods We collected 2 cases of primary pulmonary PNET to review the clinical and pathological features. Immunohistochemical staining was used to detect immune markers,and fluorescence in situ hybridization( FISH) was applied to detect EWS translocation. Results 2 patients were aged 33 years and 17 years. Microscopically,the tumor cell was composed of single small round cells in diffusion or in distribution of sheets or beams,with scant cytoplasm,oval or spindle-shaped nucleus,high mitotic count. Irregular tumor necrosis scattered in the tumor along with visible rosette structure. Immunohistochemical study showed that the tumor cells were positive for CD99,FLI-1 and Syn,while CKpan,EMA,Desmin,Cg A,TTF1,CD34 were negative. EWS / FLI1 translocations were detected positive in both the cases. 2 patients died 7months and 32 months after operation,respectively. Conclusion Primary pulmonary PNET is rare,so the selection of appropriate immune markers( CD99,FLI-1,Syn) and FISH for the detection of EWS translocation helps to improve the accuracy of diagnosis.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot