Title: Effect of curcumin on ICAM-1 and relative serum indexes in rats with metabolic syndrome
Abstract: AIM: To investigate the therapetutic effects of curcumin on metabolic syndrome (MS) in rats and the underlying mechanism. METHODS: Thirty SD male rats were randomly separated into 3 groups (n=10 in each one): control, model and curcumin groups. Rats in model and curcumin groups were treated with two-kidneys one-clipped to induce renal hypertension and fed with a high fructose diet for 4 week to induce MS. Sham-operated rats were taken at random as non-infarction control. After intragastric administration of either curcumin (200 mg/kg·d) in curcumin group or saline (200 mg/kg·d) in model and control groups for 4 weeks, serum glucose, insulin and lipid were tested. The sICAM-1 level was measured by ELISA and ICAM-1 mRNA level in artery was tested by RT-PCR. RESULTS: Compared with controls, rats in model group had higher levels of sICAM-1, serum glucose, insulin, lipid (P0.01), and curcumin restored these indexes. The ICAM-1 mRNA expression in model group was higher than that in sham-operated rats (P0.01); while in curcumin group, ICAM-1 mRNA level was comparable to that in control group (P0.05). CONCLUSION: Curcumin reduces serum glucose, insulin and lipid of MS rats and it may be related to the suppression of ICAM-1 mRNA expression and the improvement of blood vessel endothelium function.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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