Title: Effect of Nifedipine Controlled Release Tablets plus Telmisartan on the Ambulatory Blood Pressure Monitoring and Left Ventricular Diastolic Function of Elderly Patients with Hypertension
Abstract: Objective: To investigate the effect of Nifedipine Controlled Release Tablets with Telmisartan Tablets on the ABP and left ventricular diastolic function of elderly hypertension. Methods: 84 mild or moderate elderly hypertension patients from December2012 to November 2013 were divided into two groups randomly. The patients in control group took Nifedipine Controlled Release Tablets at 30~60mg/d. The observation group were dosed with 40 mg/d of Telmisartan Tablets. If the observation group failed to see the satisfactory drop, the dose of Telmisartan Tablets was adjusted to 80 mg/d. The whole research lasted for 12 weeks. The ABP and left ventricular diastolic function were observed and recorded during the research. Results: The total efficient rate of observation group was significantly higher than t the counterparts of control group(P0.05). The excellent rate of observation group was higher than that of the other group(P0.05). All the results of ABPM indexes and blood pressure load(including 24 hm SBP, 24 hm DBP, dm SBP, dm DBP, nm SBP,nm DBP) showed that both groups could control the fluctuation of blood pressure, while the observation group was superior to the control group(P0.05). The results of left ventricular diastolic function(including LVEF, LVESD, LVEDD, LVPWD, IVST) indicated that both therapeutic schedule could improve the left ventricular diastolic function at certain extent. However, the differences between the two groups did not have statistical significance. Conclusion: To treat elderly hypertension with Nifedipine Controlled Release Tablets and Telmisartan Tablets could effectively control the fluctuation of blood pressure and improve left ventricular diastolic function to some extent.
Publication Year: 2015
Publication Date: 2015-01-01
Language: en
Type: article
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