Title: Effects of combined therapy with simvastatin and candesartan on vasodilatation function in patients with hypertension and hypercholesterol
Abstract: Objective To observe the effect of combined therapy with simvastatin and candesartan on endothelium function and inflammation factor and the blood pressure control in the patients with hypertension and hypercholesterol.Methods Forty-six cases with hypertension and hypercholesterol were received candesartan 4mg per day and dietary therapy in a self-controlled study,then simvastatin 20mg per night was added as combined therpy after 8 weeks.The noninvasive ultrasonic examination was used to observe the changes of brachial artery diameter during baseline,reactive hyperemia and sublingual nitroglycerin administration,flow mediated vasodilatation(FMD) and nitroglycerin mediated vasodilatation(NMD).Blood pressure,plasma cholesterol,plasma triglyceride,insulin,blood glucose and C-reaction protein were also measured at 0,8,16 weeks.Results The levels of blood pressure were decreased significantly at 8 week after using candesartan(P0.01),combined therapy could not decrease the levels of blood pressure further.But combined therapy significantly improved flow-mediated dilator response to hyperemia compared with candesartan alone(P0.05).Conclusion The use of simvastatin in combination with candesartan improves endothelial function in hypercholesterolemic and hypertensive patients.
Publication Year: 2010
Publication Date: 2010-01-01
Language: en
Type: article
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