Title: Zidianshen I Number Decoction on Henoch-schonlein Purpura Nephritis with 45 Cases
Abstract: Objective: Discuss curative effect of purpuric nephropathy Zidianshen Ⅰ number decoction on henoch-schonlein purpura nephritis( HSPN) and influence to clotting mechanism and blood rheology. Method: Ninety children with HSPN were randomly divided into control group( 45 cases) and observation group( 45 cases) by random number table. Both groups' patients received conventional western therapy and received dipyridamole,tripterygium wilfordii polyglycoside and prednisone refer to different clinical feature. Based on control group,in observation group in the control group on basis of Zidianshen Ⅰ number decoction,1 dose / day. Course of treatment in two groups were 12 weeks. Hematuresis and proteinuria were monitored,and urine protein quantitation,blood rheology,fibrinogen( FIB),D-dimer( D-D) and fibrin degradation products( FDP) were detected at 24 hours before and after treatment. Result: The total effective rate of disease curative effect in the observation group was 95. 6% superior to 80% in the control group( P 0. 05). After treatment,the level of red blood cell in urine and 24 hours urinary albumin in the observation group were lower than those in the control group( P 0. 01). And negative conversion ratio of red blood cell in urine of the observation group was 88. 2% superior to 61. 7% of the control group,negative conversion ratio of urinary albumin was 82. 9% superior to 54. 1% in control group( P 0. 05). the level of FIB,FDP and D-D in observation group were all lower than those in control group( P 0. 01). The amelioration of whole blood viscosity( low or high shearing), whole blood reduced viscosity( low or high shearing),platelet aggregation rate and plasma viscosity of blood rheology index in observation group were superior to the control group( P 0. 01). Conclusion: Based on conventional western therapy,Zidianshen Ⅰ number decoction can reduce red blood cell in urine and white blood cell in urine of children with HSPN and promote the negative conversion of red blood cell in urine cell and white blood cell in urine,the mechanism of action may be related to ameliorating clotting and blood rheology index and reducing high clotting condition.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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