Title: Clinical Study on Low Molecular Weight Heparin in Treatment of Severe Hepatitis with Artificial Liver
Abstract: Objective To study the safety and effectiveness of low molecular weight heparin(LMWH) in treatment of severe hepatitis with artificial liver. Methods Twenty patients with severe hepatitis were divided into heparin group and LMWH group randomly. All of the patients were treated with artificial liver. The changes of hemoglobin (Hb),international normal rate(INR),activated partial thromboplastin time(APTT),fibrinogen(Fbg),thrombin time(TT) and factorⅧ were evaluated before and after the treatment with artifical liver in two groups respectively. The adverse effects during treatment were also observed. Results There was no significant difference in Hb level before and after treatment between two groups. In heparin group,APTT and TT levels increased significantly in 2 hours after treatment with artificial liver, then decreased. The INR and APTT decreased signficantly in LMWH group; The Fbg and F8 decreased significantly in two groups. In heparin group there were complications of blood pressure lowering and bleeding, but in LMWH group no complications were found. Conclusions The application of LMWH in artificial liver is effective and safe in the treatment of severe hepatitis.
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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Cited By Count: 1
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