Title: The Effect of Tanshinone II A on Apoptosis and Hypertrophy in Cardiomyocytes Induced by Angiotensin II
Abstract: ObjectiveTo study the effect of the effect of tanshinone ⅡA(TSN)on hypertrophy and apoptosis of cardiomyocytes induced by Ang Ⅱ.MethodsThe cultured neonatal rat cardiomyocytes(NRCs) were exposed to Ang Ⅱ(10~(-6) mol/L),TSN(10~(-5) mol/L)and Ang Ⅱ(10~(-6) mol/L)+TSN(10~(-5) mol/L) respectively in free-serum medium for 36 h.The expression level of apoptoic protein p53,the cell size and ~(3)H-Leucine incorporation were investigated.ResultsAs compared with control,the apoptoic protein p53 expression level(Ang Ⅱ+TAN:99 890±338 vs Ang Ⅱ:389 712±270,P0.05),the cell size(Ang Ⅱ+TAN:21.3±2.5 vs Ang Ⅱ:28.5±3.8 μm,P0.05) and protein synthesis rate of cardinmyocytes(Ang Ⅱ+TAN:1 302±96 vs Ang Ⅱ:1 900±100 cpm,P0.05) were increased significantly after Ang Ⅱ treatment(P0.05).TSN inhibited these effects induced by Ang Ⅱ(P0.05).ConclusionTSN may prevent cardiomyocytes hypertrophy and apoptosis induced by Ang Ⅱ.
Publication Year: 2006
Publication Date: 2006-01-01
Language: en
Type: article
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