Title: Sufentanil pre-dosage induces protection against acute focal cerebral ischemia-reperfusion injury in rats
Abstract: Objective To investigate whether sufentanil pre-dosage induces protection aganist acute focal cerebral ischemia-reperfusion injury in rats.Methods Forty male SD rats were randomly divided into four groups with 10 rats each.Before establishing animal model,the rats were intraperitoneally injected sufentanil 3 μg/kg(group S1),6 μg/kg(group S2),9 μg/kg(group S3)or normal saline(group C).At 30 min after injection,all rats subjected to the right middle cerebral artery occlusion(MCAO)for 120 min,which was followed by reperfusion.The neurological deficit scores(NDS)were evaluated at 24 h after reperfusion.Infarct volume,as a percentage of volume at normal cerebral hemisphere,was determined by TTC staining.Results At 24 h after reperfusion,the NDS was higher and infarct volume was less in group S1 than those in groups of S2,S3 and C(P0.05).There were no significant differences in NDS and infarct volume among groups of S2,S3 and C.Conclusion Sufentanil preconditioning can protect rat brain against ischemia-reperfusion injury.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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