Title: Antioxygen effects of Aucubio on mitochondria in diabetic rats
Abstract: Objective To investigate the effects of Aucubin on blood glucose levels and mitochondria antioxidant capacity in streptozotocin-induced diabetic rats. Methods Diabetic rats were induced by intraperitoneal injection of STZ. Rats were randomly allocated into diabetic group, low dose group,high dose group and normal control group. During and after the treatment, the general state, body weight, blood gloucose, lipid per-oxidative level and antioxidative enzymes activities in mitochondria were observed.Results The level of blood glucose and MDA in the diabetic group significantly increased, and the activities of CAT, GSH-Px and SOD vigor reduced significantly. After the administration of Aucubin, the level of blood glucose and MDA in the diabetic group reduced significantly, as well as the activities of CAT, GSH-Px and SOD increased significantly. Conclusion This study showed that Aucubin administration could reduce the level of blood glucose, improve mitochondria antioxidant capacity in diabetic rats. Thus, Aucubin may be implicated as a preventive medicine against diabetes mellitus.
Publication Year: 2008
Publication Date: 2008-01-01
Language: en
Type: article
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