Title: JEfficacy of low molecular weight heparin therapy and prevention of kidney damage in children with Henoch-Schnlein purpura
Abstract: Objective To investigate the efficacy of low molecular weight heparin therapy and prevention of kidney damage in children with Henoch-Schnlein purpura( HSP). Methods 94 cases of HSP were collected and randomly divided into study group and the control group( 47 cases each). Conventional treatment methods were used in the control group and in study group,on the basis of conventional therapy. Low molecular weight heparin was used. The duration of the main symptoms were observed after treatment. Changes of urinary albumin( Alb) and urinary β2-microglobulin( β2-MG) were detected. Nephritis incidence and the adverse reactions were observed in both groups. Results Before treatment,urinary Alb and urinary β2-MG levels did not show statistical differences. However,they were decreased after treatment. In study group,urine Alb and urinary β2-MG level after treatment were significantly lower than those of the control group( P 0. 05). Skin rash and gastrointestinal symptoms duration in study group were significantly lower than those of the control group. The incidence of nephritis was significantly lower than the control group( P 0. 05). There were no serious adverse events in both groups. Conclusion Early treatment of low molecular weight heparin can reduce the duration of the clinical symptoms of HSP,which has a significant effect of protecting kidney,and is worthy of clinical application.
Publication Year: 2014
Publication Date: 2014-01-01
Language: en
Type: article
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