Title: Clinical Observation of Adefovir Dipivoxil Combined with Lamivudine in the Treatment of Chronic Hepatitis B
Abstract: OBJECTIVE:To observe the clinical efficacy of combination therapy of adefovir and lamivudine in the treatment of chronic hepatitis B,and to carry out analysis and summary.METHODS:By retrospective method,108 outpatient and hospitalization patients with HBeAg positive chronic hepatitis B in our hospital from Jun.2007 to Sept.2010 were divided into treatment group and control group according to disease condition and will.Treatment group was given adefovir dipivoxil combined with lamivudine;control group was given lamivudine alone.ALT was detected before and after treatment,HBeAg and HBV-DNA negative rate were calculated before and after treatment,and clinical efficacy and adverse reaction rates were evaluated,too.RESULTS:After 3,6,12 months of treatment,liver function index ALT value reduced significantly in treatment group,there was statistical significance between 2 groups(P0.05);HBeAg and HBV-DNA negative rate was significantly higher than that of control group(P0.05 or P0.01);after 12 months of treatment,there was statistical significance in total effective rate of drug combination group(92.86%) and control group(73.08%,P0.01).After 12 months of treatment,3 patients in the treatment group suffered from drug resistance(5.36%),and 9 cases in the control group(17.3%),there was significant difference(P0.05).There was no statistical significance in 2 groups.CONCLUSION:Adefovir dipivoxil combined with lamivudine in the treatment of chronic hepatitis B can significantly improve the patient's liver function,decrease drug resistance,obtain affirmed curative effect.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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