Title: Clinical observation of Mesalazine combined with enema in the treatment of chronic ulcerative colitis
Abstract:Objective To observe the clinical efficacy of Mesalazine combined with enema in the treatment of chronic ulcerative colitis.Methods 40 patients were randomly assigned to two groups,with 20 cases in ea...Objective To observe the clinical efficacy of Mesalazine combined with enema in the treatment of chronic ulcerative colitis.Methods 40 patients were randomly assigned to two groups,with 20 cases in each group.Patients in the control group were given Sulfasalazine 1 g every time,4 times a day;patients in the treatment group were given oral administration of Mesalazine(1 g every time,3 times a day),in conjunction with enema(gentamicin 160 000 U,Smectite up to 6 g and Dexamethasone 5 mg added to 60 mL of normal saline).Enema was retained 2 times a day,40 min each time and 2 weeks each treatment course.The two groups were observed for two courses.Results Total effective rate was 60.0% in the control group and 85.0% in the treatment group,showing significantly differences(P 0.05).Colonoscopy score improvement was significantly better in the treatment group than in the control group(P 0.05).Treatment group showed significantly lower adverse reactions rate(45.0%) than seen in the control group(15.0%)(P 0.05).Conclusion Mesalamine combined with enema shows good treatment efficacy in the treatment of ulcerative colitis,and also has few side effect and good patient compliance,thus is worthy of further investigation and promotion.Read More
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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