Title: Olfactory neuroblastoma: clinicopathological and immunohistochemical changes of 9 cases
Abstract: ObjectiveTo investigate the clinicopathologica l and immunohistochemical features of olfactory neuroblastoma MethodsNine patients with detailed clinical data, HE staining and immunohistochemical staining were analyzed ResultsAccording to Ksdish' s staging system, the patients included 1 cases of olfactory neuroblastoma stage A, 7 cases of stage B, and 1 cases of stage C The pathological features showed small round or oval tumor cells arranged in p ieces or trabeculae by fibrous connective tissues, which contained many capillary The tumor cells had round or oval nuclei, and chromatins in small granules, and a high nucleocytoplasmic ratio. Homer-Wright rosette and (or) Flener rosette were found in some cases And acidphilic fibrillary formed by intercytoplasmic processes w as found between tumor cells. Immunohistochemiscal staining showed that neuro-specific enolase (NSE) positive in 5 cases, S-100 protein (S-100) in 4 cases, neurofilament protein (NF) in 3 cases, vimentin protein (vimentin) in 1 case, and kerat in in 1 case. Leucocyte common antigen (LCA), melanoma (HMB45), desmin protein (desmin) were all negative ConclusionNSE is the most useful diagnostic marker for olfactory neuroblastoma; NF, S-100, keratin, LCA, vimentin, HMB45, and desmin may help in the diagnosis
Publication Year: 2004
Publication Date: 2004-01-01
Language: en
Type: article
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