Title: The effect of dexmedetomidine on postoperative pain in patients receiving patient-controlled morphine
Abstract: Objective To investigate the effect of dexmedetomidine(Dex) on postoperative pain in patients receiving patient-controlled morphine.Methods Forty patients(ASA Ⅰor Ⅱ) undergoing selective operation were randomly divided into 2 groups: Dex group(group Dex,n=20) and control group(group C,n=20).Patients in Dex group were received(0.8 μg/kg) Dex and control group were received normal saline respectively by pumped infusion 30 minutes before the operation finished.All patients received a standardized(0.05 mg/kg) loading dose of morphine in postanesthesia care unit(PACU).Then they were allowed to use a patient-controlled infusion analgesia(PCIA) device giving bolus doses of morphine(0.02 mg/kg).VAS score,Ramsay sedation scale(RSS) and cumulative morphine consumption were recorded at 1,2,6,12 and 24 h after the beginning of PCIA.The incidence of postoperative nausea,vomiting and shivering was recorded.Results Compared with group C,cumulative morphine consumption in group Dex was obviously decreased(P0.05 or P0.01);the incidence of early(up to 24 h) postoperative nausea,vomiting and shivering in Dex group were significantly decreased(P0.05).Conclusion Dexmedetomidine with a single dose of 0.8 μg/kg(given 10 min by pumped infusion) 30 min before operation finished can significantly reduce postoperative morphine consumption and the incidence of postoperative nausea,vomiting and shivering.
Publication Year: 2011
Publication Date: 2011-01-01
Language: en
Type: article
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