Title: Effect of Tongjing Bushen Recipe on Oxidative Stress of Alzheimer's Disease Model Rats
Abstract: Objective:To observe the effect of Tongjing Bushen recipe on the oxidative stress of Alzheimer's disease(AD) model rats induced by Al.Methods:Eighty-four healthy SD rats,3-month old,were randomly divided into control group(group C),model group(including low-dose Al group-M1,middle-dose Al group-M2 and high-dose Al group-M3) and Chinese-medicine-recipe group(including low-dose group-N1,middle-dose group-N2 and high-dose group-N3).There were 12 rats in each group.Rats in model group were fed with conventional feed mixed with A1C13·6H2O for three months to establish the AD model.The successful AD animal model was proved by detecting the learning and memory ability with Y-electric maze.The escaping latent period was obviously prolonged,and the correct rate of escape was significantly decreased in group M compared with that of control group.Rats in Chinese medicine group were fed with high-dose Al and Tongjing Bushen recipe.The levels of superoxide dismutase(SOD),glutathione peroxidase(GSH-PX) and malondialdehyde(MDA) in serum and brain tissues were detected and compared between groups.Results:Compared with group C,the activities of SOD and GSH-PX in brain tissues and serum were strikingly decreased,the content of MDA was strikingly increased,in group M2 and group M3(P 0.01).There were no significant differences in each index between group M1 and group C,and between group M2 and group M3(P 0.05).The activities of SOD and GSH-PX were significantly increased,and the content of MDA significantly decreased in group N2 and group N3 compared with those of group M3(P 0.01).There were no significant differences in each index between group N1 and group M3,and between group N2 and group N3(P 0.05).Conclusion:The excessive intake of Al caused the state of intense oxidative stress in rats.Tongjing Bushen recipe strikingly increased the antioxidant ability and protected the central nervous system in rats.
Publication Year: 2012
Publication Date: 2012-01-01
Language: en
Type: article
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