Title: Clinical study of sentinel lymph nodes intraoperatively mapping on colon cancer
Abstract: Objective To study the feasibility of the sentinel lymph node(SLN) mapping during operation and clinical significanc in diagnosis and treatment of colon cancer.Methods SLN was mapped during operation by staining method with isosulfan blue in 73 cases of colon cancer.All lymph nodes were checked by routine pathological technique,some of which were negative in routine HE staining were further analyzed with cytokratin AE1/AE3(CK,AE1/AE3) via immunohistochemistical staining.Results One hundred and fifty-seven SLNs were identified in 72 patients,and the mean number was 2.2.116 SLNs from 53 cases with lymph node metastasis were found by routine pathologic examnation.Sensitivity and accuracy of the SLN biopsy were 93.0% and 94.5%,respectively.Micrometastasis can be identified by immunohistochemistical staining,then the false-negative in metastasis identification can be reduced.Conclusions The SLN mapping during operation is feasible.The SLN can accurately predict the status of regional lymph nodes,SLN could indicate the range of abnormal lymph node drainage and improve accuracy rate of pathologic staging.But the feasibility and security for this technique to substitute the conventional surgical operation should be evaluated by prospective random comparison studies on multicenter,large samples.
Publication Year: 2009
Publication Date: 2009-01-01
Language: en
Type: article
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