Title: Influence of paraquat on oxidative stress of dopaminergic neuron in substantia nigra of mice
Abstract: Objective To explore the oxidative stress pathogenesis of Parkinson's disease(PD) induced by paraquat in substantia nigra of mice. Methods The model of PD was established by oral administration of paraquat to mice.The spectrophotometry was used to determine the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-PX) and the content of malondialdehyde(MDA) in substantia nigra.At the same time,number of tyrosine hydroxylase(TH) positive neurons in substantia nigra of mice was estimated by immunohistochemistry. Results The activities of SOD and GSH-PX were significantly decreased,and the content of MDA was increased in paraquat-treated mice compared to that of mice treated by saline taken orally(P0.05).Number of TH positive neurons in substantia nigra of mice was also significantly decreased(P0.01). Conclusion Paraquat can induce mice to appear a series of behaviors that are similar to PD.The decreased activities of SOD and GSH-PX,and increased content of MDA in substantia nigra of mice indicate that oxidative stress may be involved in the pathogenic mechanism of PD induced by paraquat.
Publication Year: 2007
Publication Date: 2007-01-01
Language: en
Type: article
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