Title: Bone mineral density and age-related bone loss in 2111 healthy women in Shanghai
Abstract:Objective To establish the data base of bone mineral density(BMD)in healthy women in Shanghai for reference and to provide evidence for diagnosing and evaluating the effects of prevention and treatmen...Objective To establish the data base of bone mineral density(BMD)in healthy women in Shanghai for reference and to provide evidence for diagnosing and evaluating the effects of prevention and treatment of osteoporosis. Methods The study population consisted of 2111 healthy women aged 20-84 years.They were divided into 13 groups by every 5 year interval.BMD of lumbar spines(L 1-4 ),femoral neck(Neck),trochanter(Troch),intertrochanteric(Inter)and Ward's triangle(Ward's)were measured by dual energy X ray absorptiometry.(DXA,Hologic QDR-2000). Results The peak bone mass (PBM) for each site appeared as follows:30-34 years old in L 1-4 ,and 20-24 years old in proximal femur.BMD decreased with increasing age after PBM appeared.BMD rose in the group aged 40-44,in the shape of ravine.There were two accelerated bone loss periods after menopause:10 and 26-30 years.In the first period,the bone loss rate was 1 4%-3 2% annually while in the second period,it was 1 1%-1 4% annually.The accumulative bone loss percentage(compared with PBM)gradually increased with aging.It reached 28%-58% at the age of 80.The higher rate of detecting osteoporosis was at L 1-4 and Ward's.The rates were 48% for L 1-4 and 43% for Ward's in the group aged 60-64(according to WHO criteria:T score-2 5SD).After the age of 75,it reached 83% in Ward's. Conclusion PBM for each skeleton site appeared in different ages.The two accelerated bone loss periods menopause,should be actively intervened to prevent osteoporosis.Bone loss first occurs in the sites which mainly consist of trabecular bone,such as Ward's and L 1-4 .These two sites were the sensitive sites for detecting osteoporosis.\;Read More
Publication Year: 2002
Publication Date: 2002-01-01
Language: en
Type: article
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Cited By Count: 4
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